Selected publications

Selected publications from our research group

Nielsen LR, Stensgaard S, Meldgaard P, and Sorensen BS. “ctDNA-based minimal residual disease detection in lung cancer patients treated with curative intended chemoradiotherapy using a clinically transferable approach.Cancer Treat Res Commun. 25:39:100802 (2024). https://doi.org/10.1016/j.ctarc.2024.100802

Maansson, C. T., Thomsen, L. S., Meldgaard, P., Nielsen, A. L. and Sorensen, B. S. "Integration of Cell-Free DNA End Motifs and Fragment Lengths Can Identify Active Genes in Liquid Biopsies." Int J Mol Sci. 25(2) (2024). https://doi.org/10.3390/ijms25021243

Maansson, C. T., Thomsen, L. S., Stokkebro, L., Dissing, L. S., Ulhoi, M. P., Nielsen, A. L., Meldgaard, P. and Sorensen, B. S. "In vitro size-selection of short circulating tumor DNA fragments from late-stage lung cancer patients enhance the detection of mutations and aneuploidies." The Journal of Liquid Biopsy. 4: 100141 (2024). https://doi.org/10.1016/j.jlb.2024.100141

Stensgaard, S., Thomsen, A., Helstrup, S., Meldgaard, P. and Sorensen, B. S. "Blood tumor mutational burden and dynamic changes in circulating tumor DNA predict response to pembrolizumab treatment in advanced non-small cell lung cancer." Translational Lung Cancer Research. 12(5): 971-984 (2023). https://doi.org/10.21037/tlcr-22-818

Stensgaard, S., Thomsen, A., Helstrup, S., Meldgaard, P. and Sorensen, B. S. "Plasma Immune Proteins and Circulating Tumor DNA Predict the Clinical Outcome for Non-Small-Cell Lung Cancer Treated with an Immune Checkpoint Inhibitor." Cancers (Basel). 15(23) (2023). https://doi.org/10.3390/cancers15235628

Maansson, C. T., Meldgaard, P. and Sorensen, B. S. "Can liquid biopsy dynamics stratify patients with small cell lung cancer?" Translational Lung Cancer Research. 12(12): 2565-2569 (2023). https://doi.org/10.21037/tlcr-23-665

Larsen, T. V., Maansson, C. T., Daugaard, T. F., Andresen, B. S., Sorensen, B. S. and Nielsen, A. L. "Trans-Regulation of Alternative PD-L1 mRNA Processing by CDK12 in Non-Small-Cell Lung Cancer Cells." Cells. 12(24): 2844 (2023). https://doi.org/10.3390/cells12242844

Trier Maansson, C., Meldgaard, P., Stougaard, M., Nielsen, A. L. and Sorensen, B. S. "Cell-free chromatin immunoprecipitation can determine tumor gene expression in lung cancer patients." Mol Oncol. (2023). https://doi.org/10.1002/1878-0261.13394

Larsen, T. V., Dybdal, N., Daugaard, T. F., Lade-Keller, J., Lin, L., Sorensen, B. S. and Nielsen, A. L. "Examination of the Functional Relationship between PD-L1 DNA Methylation and mRNA Expression in Non-Small-Cell Lung Cancer." Cancers (Basel). 15(6) (2023). https://doi.org/10.3390/cancers15061909

Maansson, C. T., Helstrup, S., Ebert, E. B. F., Meldgaard, P. and Sorensen, B. S. "Circulating immune response proteins predict the outcome following disease progression of osimertinib treated epidermal growth factor receptor-positive non-small cell lung cancer patients." Transl Lung Cancer Res. 12(1): 14-26 (2023). https://doi.org/10.21037/tlcr-22-577

Maansson, C. T., Andersen, E. R., Ulhoi, M. P., Meldgaard, P. and Sorensen, B. S. "DNAfusion: an R/Bioconductor package for increased sensitivity of detecting gene fusions in liquid biopsies." BMC Bioinformatics. 24(1): 131 (2023). https://doi.org/10.1186/s12859-023-05259-3

Hansen, K. H., Johansen, J. S., Urbanska, E. M., Meldgaard, P., Hjorth-Hansen, P., Kristiansen, C., Stelmach, M., Santoni-Rugiu, E., Ulhøi, M. P., Dydensborg, A. B., Dünweber, C. and Andersen, J. L. "Clinical outcomes of ALK+ non-small cell lung cancer in Denmark." Acta Oncol. 62(12): 1775-1783 (2023). https://doi.org/10.1080/0284186x.2023.2263153

Eide, I. J. Z., Stensgaard, S., Helland, Å., Ekman, S., Mellemgaard, A., Hansen, K. H., Cicenas, S., Koivunen, J., Grønberg, B. H., Sørensen, B. S. and Brustugun, O. T. "Osimertinib in non-small cell lung cancer with uncommon EGFR-mutations: a post-hoc subgroup analysis with pooled data from two phase II clinical trials." Transl Lung Cancer Res. 11(6): 953-963 (2022). https://doi.org/10.21037/tlcr-21-995

Dissing, J. G., Ulhøi, M. P., Sorensen, B. S. and Meldgaard, P. "Tumoral PD-L1 does not impact time to treatment discontinuation in EGFR mutated non-small cell lung cancer patients treated with EGFR tyrosine kinase inhibitor-a Danish cohort study." Transl Lung Cancer Res. 11(9): 1796-1808 (2022). https://doi.org/10.21037/tlcr-22-211

Månsson, C. T., Vad-Nielsen, J., Meldgaard, P., Nielsen, A. L. and Sorensen, B. S. "EGFR transcription in non-small-cell lung cancer tumours can be revealed in ctDNA by cell-free chromatin immunoprecipitation (cfChIP)." Mol Oncol. 15(11): 2868-2876 (2021). https://doi.org/10.1002/1878-0261.13093

Ulhoi, M. P., Sorensen, B. S. and Meldgaard, P. "Alectinib-Induced Pleural and Pericardial Effusions in ALK-Positive NSCLC." Case Rep Oncol. 14(3): 1323-1327 (2021). https://doi.org/10.1159/000518081

Clement, M. S., Ebert, E. B. F., Meldgaard, P. and Sorensen, B. S. "Co-occurring MET amplification predicts inferior clinical response to first line erlotinib in advanced stage EGFR-mutated NSCLC patients." Clinical Lung Cancer. (2021). https://doi.org/10.1016/j.cllc.2021.05.002

Clement, M. S., Gammelgaard, K. R., Nielsen, A. L. and Sorensen, B. S. "Epithelial-to-mesenchymal transition is a resistance mechanism to sequential MET-TKI treatment of MET-amplified EGFR-TKI resistant non-small cell lung cancer cells." Transl Lung Cancer Res. 9(5): 1904-1914 (2020). https://doi.org/10.21037/tlcr-20-522

Vad-Nielsen, J., Meldgaard, P., Sorensen, B. S. and Nielsen, A. L. "Cell-free Chromatin Immunoprecipitation (cfChIP) from blood plasma can determine gene-expression in tumors from non-small-cell lung cancer patients." Lung Cancer. 147: 244-251 (2020). https://doi.org/10.1016/j.lungcan.2020.07.023

Ebert, E. B. F., McCulloch, T., Hansen, K. H., Linnet, H., Sorensen, B. and Meldgaard, P. "Clearing of circulating tumour DNA predicts clinical response to first line tyrosine kinase inhibitors in advanced epidermal growth factor receptor mutated non-small cell lung cancer." Lung Cancer. 141: 37-43 (2020). https://doi.org/10.1016/j.lungcan.2019.12.016

Boysen Fynboe Ebert, E., McCulloch, T., Holmskov Hansen, K., Linnet, H., Sorensen, B. and Meldgaard, P. "Clearing of circulating tumour DNA predicts clinical response to osimertinib in EGFR mutated lung cancer patients." Lung Cancer. 143: 67-72 (2020). https://doi.org/10.1016/j.lungcan.2020.03.020

Madsen, A. T., Winther-Larsen, A., McCulloch, T., Meldgaard, P. and Sorensen, B. S. "Genomic Profiling of Circulating Tumor DNA Predicts Outcome and Demonstrates Tumor Evolution in ALK-Positive Non-Small Cell Lung Cancer Patients." Cancers (Basel). 12(4) (2020). https://doi.org/10.3390/cancers12040947