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Department of Clinical Medicine

Research Unit for Molecular Medicine (MMF)

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Bertelsen MB , Tsang E , Palmfeldt J, Kristoffersen CH, Nisavic M , Gothelf KV. 2024. A Diketopinic Reagent for the Reversible Bioconjugation to Arginine Residues on Native Antibodies. Bioconjugate Chemistry. 35(11). https://doi.org/10.1021/acs.bioconjchem.4c00317

TRACERx Consortium. 2024. Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx (Nature, (2023), 616, 7957, (525-533), 10.1038/s41586-023-05783-5). Nature. 631(8022):E15. https://doi.org/10.1038/s41586-024-07738-w

Razim A, Zabłocka A, Schmid A, Thaler M, Černý V, Weinmayer T, Whitehead B, Martens A, Skalska M, Morandi M, et al. 2024. Bacterial extracellular vesicles as intranasal postbiotics: Detailed characterization and interaction with airway cells. Journal of Extracellular Vesicles. 13(10):Article e70004. https://doi.org/10.1002/jev2.70004

Lin Y , Rasmussen MH , Christensen MH , Frydendahl A, Maretty L, Andersen CL , Besenbacher S. 2024. Evaluating Bioinformatics Processing of Somatic Variant Detection in cfDNA Using Targeted Sequencing with UMIs. International Journal of Molecular Sciences . 25(21):Article 11439. https://doi.org/10.3390/ijms252111439

Steininger F , Palmfeldt J , Koren K , Kalinichev AV. 2024. Exploiting the pH-Cross Sensitivity of Ion-Selective Optodes to Broaden Their Response Range. ACS Sensors. 9(9):4555-4559. https://doi.org/10.1021/acssensors.4c01481

Cömert C , Kjær-Sørensen K , Hansen J , Carlsen J , Just J, Meaney BF, Østergaard E, Luo Y , Oxvig C , Schmidt-Laursen L, et al. 2024. HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis. Molecular Metabolism. 88:Article 102009. https://doi.org/10.1016/j.molmet.2024.102009

Mosegaard S , Twayana KS, Denis SW, Kroon J, Schomakers BV, van Weeghel M, Houtkooper RH, Olsen RKJ , Holm CK. 2024. Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS. FASEB BioAdvances. 6(9):337-350. https://doi.org/10.1096/fba.2024-00060

Johannessen AL , Alstrup M , Hjortdal VE , Palmfeldt J , Offersen BV , Mohanakumar S. 2024. Increased Microvascular Filtration and Vascular Endothelial Growth Factor-D associated with Changed Lymphatic Vessel Morphology in Breast Cancer Treated Patients. Plastic and Reconstructive Surgery - Global Open. 12(7):Article e5968. https://doi.org/10.1097/GOX.0000000000005968

Berglund A , Johannsen EB , Skakkebæk A , Chang S, Rohayem J, Laurentino S, Hørlyck A , Drue SO , Bak EN, Fedder J, et al. 2024. Integration of long-read sequencing, DNA methylation and gene expression reveals heterogeneity in Y chromosome segment lengths in phenotypic males with 46,XX testicular disorder/difference of sex development. Biology of Sex Differences. 15(1):Article 77. https://doi.org/10.1186/s13293-024-00654-8

Øzdemir CM, Nielsen MM, Liimatta J, Voegel CD, Elzenaty RN, Wasehuus VS, Lind-Holst M , Ornstrup MJ, Gram SB, Ousager LB, et al. 2024. Late diagnosis of partial 3β-hydroxysteroid dehydrogenase type 2 deficiency – characterization of a new genetic variant. Endocrinology, Diabetes and Metabolism Case Reports. 2024(3):Article 23-0090. https://doi.org/10.1530/EDM-23-0090

Atay JCL , Elsborg SH , Palmfeldt J , Nejsum LN , Nørregaard R. 2024. Recovery of Water Homeostasis in Adenine-Induced Kidney Disease Is Mediated by Increased AQP2 Membrane Targeting. International Journal of Molecular Sciences (Online). 25(6):Article 3447. https://doi.org/10.3390/ijms25063447

Eggertsen PP , Palmfeldt J, Schytz HW, Hay D, Olsen RKJ , Nielsen JF. 2024. Serum calcitonin gene‑related peptide in patients with persistent post‑concussion symptoms, including headache: a cohort study. Journal of Neurology. 271(5):2458-2472. https://doi.org/10.1007/s00415-024-12181-y

Eggertsen PP , Palmfeldt J , Pedersen AR , Frederiksen O-V , Olsen RKJ , Nielsen JF. 2024. Serum neurofilament light chain, inflammatory markers, and kynurenine metabolites in patients with persistent post-concussion symptoms: A cohort study. Journal of the Neurological Sciences. 460:Article 123016. https://doi.org/10.1016/j.jns.2024.123016

Fahlquist-Hagert C , Wittenborn TR , Terczyńska-Dyla E , Kastberg KS, Yang E, Rallistan AN, Markett QR, Winther G , Fonager S , Voss LF, et al. 2023. Antigen presentation by B cells enables epitope spreading across an MHC barrier. Nature Communications. 14(1):Article 6941. https://doi.org/10.1038/s41467-023-42541-7

Ghavami M, Pedersen JG, Kjeldsen RB, Alstrup AKO, Zhang Z, Koulianou V, Palmfeldt J , Vorup-Jensen T, Thamdrup LHE, Boisen A. 2023. A self-unfolding proximity enabling device for oral delivery of macromolecules. Journal of Controlled Release. 361:40-52. https://doi.org/10.1016/j.jconrel.2023.07.041

Frandsen M , El-Chami K , Palmfeldt J , Smidt JM , Langballe MET , Sandahl A , Gothelf KV. 2023. Automated Solid-Phase Oligo(disulfide) Synthesis. Angewandte Chemie International Edition. 62(23):Article e202303170. https://doi.org/10.1002/anie.202303170

Moeslund N, Zhang ZL, Dalsgaard FF , Glenting SB , Ilkjaer LB , Ryhammer P , Palmfeldt J , Pedersen M, Erasmus M, Eiskjaer H. 2023. Clamping of the Aortic Arch Vessels During Normothermic Regional Perfusion Does Not Negatively Affect Donor Cardiac Function in Donation After Circulatory Death. Transplantation. 107(1):E3-E10. https://doi.org/10.1097/TP.0000000000004298

Jørgensen CS , Kamperis K , Knudsen JH , Kjeldsen M , Christensen JH , Borch L , Rittig S , Palmfeldt J. 2023. Differences in the urinary metabolome and proteome between wet and dry nights in children with monosymptomatic nocturnal enuresis and nocturnal polyuria. Pediatric nephrology (Berlin, Germany). 38(10):3347-3358. https://doi.org/10.1007/s00467-023-05963-5

Skakkebæk A , Kjær-Sørensen K , Matchkov VV , Christensen LL , Just J , Cömert C, Andersen NH, Oxvig C , Gravholt CH. 2023. Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration. Scientific Reports. 13(1):Article 12089. https://doi.org/10.1038/s41598-023-38867-3

Schmid AM, Razim A, Wysmołek M, Kerekes D, Haunstetter M, Kohl P, Brazhnikov G, Geissler N, Thaler M, Krčmářová E, et al. 2023. Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice. Cell Communication and Signaling. 21(1):Article 297. https://doi.org/10.1186/s12964-023-01329-4

Agergaard J , Yamin Ali Khan B , Engell-Sørensen T, Schiøttz-Christensen B, Jørgen Østergaard L, Hejbøl EK, Schrøder HD, Andersen H, Blicher JU, Holm Pedersen T, et al. 2023. Myopathy as a cause of Long COVID fatigue: Evidence from quantitative and single fiber EMG and muscle histopathology. Clinical Neurophysiology. 148:65-75. https://doi.org/10.1016/j.clinph.2023.01.010

Jeppesen LD , Lildballe DL , Hatt L , Hedegaard J , Singh R, Toft CLF, Schelde P, Pedersen AS , Knudsen M , Vogel I. 2023. Noninvasive Prenatal Screening for Cystic Fibrosis Using Circulating Trophoblasts: Detection of the 50 Most Common Disease-Causing Variants. Obstetrical and Gynecological Survey. 78(7):393-395. https://doi.org/10.1097/01.ogx.0000947140.57660.b6

Lund M, Heaton R, Hargreaves IP, Gregersen N , Olsen RKJ. 2023. Odd- and even-numbered medium-chained fatty acids protect against glutathione depletion in very long-chain acyl-CoA dehydrogenase deficiency. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1868(2):Article 159248. https://doi.org/10.1016/j.bbalip.2022.159248

Nisavic M , Wørmer GJ , Nielsen CS, Jeppesen SM, Palmfeldt J , Poulsen TB. 2023. oxSTEF Reagents Are Tunable and Versatile Electrophiles for Selective Disulfide-Rebridging of Native Proteins. Bioconjugate Chemistry. 34(6):994-1003. https://doi.org/10.1021/acs.bioconjchem.3c00005

Eggertsen PP , Hansen J , Andersen ML , Nielsen JF , Olsen RKJ , Palmfeldt J. 2023. Simultaneous measurement of kynurenine metabolites and explorative metabolomics using liquid chromatography-mass spectrometry: A novel accurate method applied to serum and plasma samples from a large healthy cohort. Journal of Pharmaceutical and Biomedical Analysis. 227:Article 115304. https://doi.org/10.1016/j.jpba.2023.115304

Curnock R, Yalci K, Palmfeldt J, Jäättelä M, Liu B, Carroll B. 2023. TFEB-dependent lysosome biogenesis is required for senescence. The EMBO Journal. 42(9):e111241. https://doi.org/10.15252/embj.2022111241

Mahía A , Kiib AE , Nisavic M , Svenningsen EB , Palmfeldt J , Poulsen TB. 2023. α-Lactam Electrophiles for Covalent Chemical Biology. Angewandte Chemie - International Edition. 62(26):Article e202304142. https://doi.org/10.1002/anie.202304142

Wu A, Wolley MJ, Wu Q, Cowley D, Palmfeldt J, Welling PA, Fenton RA, Stowasser M. 2022. Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles. Kidney360. 3(5):910-921. https://doi.org/10.34067/KID.0000362022

Ipsen MB , Sørensen EMG , Thomsen EA , Weiss S , Haldrup J , Dalby A , Palmfeldt J , Bross P , Rasmussen M , Fredsøe J, et al. 2022. A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer. Oncogene. 41(37):4271-4281. https://doi.org/10.1038/s41388-022-02427-2

Dinesen A , Winther A, Wall A, Märcher A , Palmfeldt J, Chudasama V, Wengel J, Gothelf KV, Baker JR, Howard KA. 2022. Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly. Bioconjugate Chemistry. 33(2):333-342. https://doi.org/10.1021/acs.bioconjchem.1c00561

Dinesen A , Winther A, Wall A, Märcher A , Palmfeldt J, Chudasama V, Wengel J, Gothelf KV, Baker JR, Howard K. 2022. An Albumin Biomolecular Drug Design Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Assembly. Poster session presented at Controlled Release Society 2022 Annual Meeting, Montreal, Quebec, Canada.

Sabaratnam R, Skov V, Paulsen SK, Juhl S, Kruse R, Hansen T, Halkier C, Kristensen JM, Vind BF, Richelsen B, et al. 2022. A Signature of Exaggerated Adipose Tissue Dysfunction in Type 2 Diabetes Is Linked to Low Plasma Adiponectin and Increased Transcriptional Activation of Proteasomal Degradation in Muscle. Cells. 11(13):Article 2005. https://doi.org/10.3390/cells11132005

Gögenur M, Lindbjerg Andersen C, Gögenur I. 2022. ASO Author Reflections: Is ctDNA Detection an Accurate Measure of the Risk of Recurrence in Patients Undergoing Neoadjuvant Treatment?. Annals of Surgical Oncology. 29(13):8675. https://doi.org/10.1245/s10434-022-12378-3

Mehlsen J, Brinth L, Pors K, Varming K, Wallukat G, Olsen RKJ. 2022. Autoimmunity in patients reporting long-term complications after exposure to human papilloma virus vaccination. Journal of Autoimmunity. 133:Article 102921. https://doi.org/10.1016/j.jaut.2022.102921

Amidi A , Buskbjerg CR , Damholdt MF , Dahlgaard J, Thorndike FP, Ritterband L, Zachariae R. 2022. Changes in sleep following internet-delivered cognitive-behavioral therapy for insomnia in women treated for breast cancer: A 3-year follow-up assessment. Sleep Medicine. 96:35-41. https://doi.org/10.1016/j.sleep.2022.04.020

Yépez VA, Gusic M, Kopajtich R, Mertes C, Smith NH, Alston CL, Ban R, Beblo S, Berutti R, Blessing H, et al. 2022. Clinical implementation of RNA sequencing for Mendelian disease diagnostics. Genome Medicine. 14(1):Article 38. https://doi.org/10.1186/s13073-022-01019-9

Wen B, Tang S, Lv X, Li D, Xu J, Olsen RKJ, Zhao Y, Li W, Wang T, Shao K, et al. 2022. Clinical, pathological and genetic features and follow-up of 110 patients with late-onset MADD: A single-center retrospective study. Human Molecular Genetics. 31(7):1115-1129. https://doi.org/10.1093/hmg/ddab308

Fruekilde SK , Bailey CJ, Lambertsen KL, Clausen BH, Carlsen J, Xu NL, Drasbek KR , Gutiérrez-Jiménez E. 2022. Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation. Journal of Cerebral Blood Flow and Metabolism. 42(12):2303-2317. https://doi.org/10.1177/0271678X221112278

Moeslund N, Long Zhang Z, Bo Ilkjaer L , Ryhammer PK, Cramer C, Palmfeldt J , Pedersen M, Erasmus ME, Tsui S, Eiskjaer H. 2022. High Oxygenation During Normothermic Regional Perfusion After Circulatory Death Is Beneficial on Donor Cardiac Function in a Porcine Model. Transplantation. 106(7):e326-e335. https://doi.org/10.1097/TP.0000000000004164

Furuya H, Sasaki Y, Chen R, Peres R, Hokutan K, Murakami K, Kim N, Chan OTM, Pagano I, Dyrskjøt L, et al. 2022. PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity. Scientific Reports. 12(1):Article 12186. https://doi.org/10.1038/s41598-022-16518-3

Carlsen J , Gutiérrez-Jiménez E , Østergaard L , Palmfeldt J. 2022. Proteomes of the TG-SWDI Murine Model of Alzheimer's disease. Poster session presented at Danish Proteomics Society (DAPSOC) Symposium, Odense, Denmark.

Svenningsen EB , Ottosen RN , Jørgensen KH , Nisavic M , Larsen CK , Hansen BK, Wang Y, Lindorff-Larsen K, Tørring T, Hacker SM, et al. 2022. The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21. RSC Chemical Biology. 3(10):1216-1229. https://doi.org/10.1039/d2cb00161f

Sellmer A , Henriksen TB , Palmfeldt J , Bech BH , Astono J, Bennike TB, Hjortdal VE. 2022. The Patent Ductus Arteriosus in Extremely Preterm Neonates Is More than a Hemodynamic Challenge: New Molecular Insights. Biomolecules. 12(9):Article 1179. https://doi.org/10.3390/biom12091179

Paternoster V , Cömert C , Kirk LS , la Cour SH , Fryland T , Fernandez-Guerra P , Stougaard M , Nyengaard JR , Qvist P , Bross P, et al. 2022. The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation. Translational Psychiatry. 12(1):Article 319. https://doi.org/10.1038/s41398-022-02053-2

Login FH , Palmfeldt J, Cheah J, Yamada S, Nejsum LN. 2021. Aquaporin-5 regulation of cell-cell adhesion proteins: an elusive "tail" story. American Journal of Physiology: Cell Physiology. 320(3):C282-C292. https://doi.org/10.1152/ajpcell.00496.2020

Märcher A , Palmfeldt J , Nisavic M , Gothelf KV. 2021. A Reagent for Amine-Directed Conjugation to IgG1 Antibodies. Angewandte Chemie International Edition. 60(12):6539-6544. https://doi.org/10.1002/anie.202013911

Djernis D, OToole MS , Fjorback LO, Svenningsen H, Mehlsen MY, Stigsdottir U, Dahlgaard J. 2021. A Short Mindfulness Retreat for Students to Reduce Stress and Promote Self-Compassion: Pilot Randomised Controlled Trial Exploring Both an Indoor and a Natural Outdoor Retreat Setting. Healthcare. 9(7):Article 910. https://doi.org/10.3390/healthcare9070910

Lund M , Andersen KG, Heaton R, Hargreaves IP, Gregersen N , Olsen RKJ. 2021. Bezafibrate activation of PPAR drives disturbances in mitochondrial redox bioenergetics and decreases the viability of cells from patients with VLCAD deficiency. B B A - Molecular Basis of Disease. 1867(6):Article 166100. https://doi.org/10.1016/j.bbadis.2021.166100

Fernandez-Guerra P, Gonzalez-Ebsen AC, Boonen SE, Courraud J, Gregersen N , Mehlsen J , Palmfeldt J , Olsen RKJ, Brinth LS. 2021. Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory Study. Biomolecules. 11(7):Article 961. https://doi.org/10.3390/biom11070961

Henriques BJ, Katrine Jentoft Olsen R, Gomes CM, Bross P. 2021. Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease. Gene. 776:Article 145407. https://doi.org/10.1016/j.gene.2021.145407

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Helle Just