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Department of Clinical Medicine

Research Unit for Molecular Medicine (MMF)

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Ghavami M, Pedersen JG, Kjeldsen RB, Alstrup AKO, Zhang Z, Koulianou V, Palmfeldt J , Vorup-Jensen T, Thamdrup LHE, Boisen A. 2023. A self-unfolding proximity enabling device for oral delivery of macromolecules. Journal of Controlled Release. 361:40-52. https://doi.org/10.1016/j.jconrel.2023.07.041, https://doi.org/10.1016/j.jconrel.2023.07.041

Frandsen M , El-Chami K , Palmfeldt J , Smidt JM , Langballe MET , Sandahl A , Gothelf KV. 2023. Automated Solid-Phase Oligo(disulfide) Synthesis. Angewandte Chemie International Edition. 62(23):Article e202303170. https://doi.org/10.1002/anie.202303170

Moeslund N, Zhang ZL, Dalsgaard FF , Glenting SB , Ilkjaer LB , Ryhammer P , Palmfeldt J , Pedersen M, Erasmus M, Eiskjaer H. 2023. Clamping of the Aortic Arch Vessels During Normothermic Regional Perfusion Does Not Negatively Affect Donor Cardiac Function in Donation After Circulatory Death. Transplantation. 107(1):E3-E10. https://doi.org/10.1097/TP.0000000000004298

Jørgensen CS , Kamperis K , Knudsen JH , Kjeldsen M , Christensen JH , Borch L , Rittig S , Palmfeldt J. 2023. Differences in the urinary metabolome and proteome between wet and dry nights in children with monosymptomatic nocturnal enuresis and nocturnal polyuria. Pediatric nephrology (Berlin, Germany). 38(10):3347-3358. https://doi.org/10.1007/s00467-023-05963-5

Skakkebæk A , Kjær-Sørensen K , Matchkov VV , Christensen LL , Just J , Cömert C, Andersen NH, Oxvig C , Gravholt CH. 2023. Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration. Scientific Reports. 13(1):Article 12089. https://doi.org/10.1038/s41598-023-38867-3

Agergaard J , Yamin Ali Khan B , Engell-Sørensen T, Schiøttz-Christensen B, Jørgen Østergaard L, Hejbøl EK, Schrøder HD, Andersen H, Blicher JU, Holm Pedersen T, et al. 2023. Myopathy as a cause of Long COVID fatigue: Evidence from quantitative and single fiber EMG and muscle histopathology. Clinical Neurophysiology. 148:65-75. https://doi.org/10.1016/j.clinph.2023.01.010

Lund M, Heaton R, Hargreaves IP, Gregersen N , Olsen RKJ. 2023. Odd- and even-numbered medium-chained fatty acids protect against glutathione depletion in very long-chain acyl-CoA dehydrogenase deficiency. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1868(2):Article 159248. https://doi.org/10.1016/j.bbalip.2022.159248

Nisavic M , Wørmer GJ , Nielsen CS, Jeppesen SM, Palmfeldt J , Poulsen TB. 2023. oxSTEF Reagents Are Tunable and Versatile Electrophiles for Selective Disulfide-Rebridging of Native Proteins. Bioconjugate Chemistry. 34(6):994-1003. https://doi.org/10.1021/acs.bioconjchem.3c00005

Curnock R, Yalci K, Palmfeldt J, Jäättelä M, Liu B, Carroll B. 2023. TFEB-dependent lysosome biogenesis is required for senescence. The EMBO Journal. 42(9):e111241. https://doi.org/10.15252/embj.2022111241

Wu A, Wolley MJ, Wu Q, Cowley D, Palmfeldt J, Welling PA, Fenton RA, Stowasser M. 2022. Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles. Kidney360. 3(5):910-921. https://doi.org/10.34067/KID.0000362022

Ipsen MB , Sørensen EMG , Thomsen EA , Weiss S , Haldrup J , Dalby A , Palmfeldt J , Bross P , Rasmussen M , Fredsøe J, et al. 2022. A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer. Oncogene. 41(37):4271-4281. https://doi.org/10.1038/s41388-022-02427-2

Dinesen A , Winther A, Wall A, Märcher A , Palmfeldt J, Chudasama V, Wengel J, Gothelf KV, Baker JR, Howard KA. 2022. Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly. Bioconjugate Chemistry. 33(2):333-342. https://doi.org/10.1021/acs.bioconjchem.1c00561

Dinesen A , Winther A, Wall A, Märcher A , Palmfeldt J, Chudasama V, Wengel J, Gothelf KV, Baker JR, Howard K. 2022. An Albumin Biomolecular Drug Design Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Assembly. Poster session presented at Controlled Release Society 2022 Annual Meeting, Montreal, Quebec, Canada.

Sabaratnam R, Skov V, Paulsen SK, Juhl S, Kruse R, Hansen T, Halkier C, Kristensen JM, Vind BF, Richelsen B, et al. 2022. A Signature of Exaggerated Adipose Tissue Dysfunction in Type 2 Diabetes Is Linked to Low Plasma Adiponectin and Increased Transcriptional Activation of Proteasomal Degradation in Muscle. Cells. 11(13):Article 2005. https://doi.org/10.3390/cells11132005

Gögenur M, Lindbjerg Andersen C, Gögenur I. 2022. ASO Author Reflections: Is ctDNA Detection an Accurate Measure of the Risk of Recurrence in Patients Undergoing Neoadjuvant Treatment?. Annals of Surgical Oncology. 29(13):8675. https://doi.org/10.1245/s10434-022-12378-3

Mehlsen J, Brinth L, Pors K, Varming K, Wallukat G, Olsen RKJ. 2022. Autoimmunity in patients reporting long-term complications after exposure to human papilloma virus vaccination. Journal of Autoimmunity. 133:Article 102921. https://doi.org/10.1016/j.jaut.2022.102921

Amidi A , Buskbjerg CR , Damholdt MF , Dahlgaard J, Thorndike FP, Ritterband L, Zachariae R. 2022. Changes in sleep following internet-delivered cognitive-behavioral therapy for insomnia in women treated for breast cancer: A 3-year follow-up assessment. Sleep Medicine. 96:35-41. https://doi.org/10.1016/j.sleep.2022.04.020

Yépez VA, Gusic M, Kopajtich R, Mertes C, Smith NH, Alston CL, Ban R, Beblo S, Berutti R, Blessing H, et al. 2022. Clinical implementation of RNA sequencing for Mendelian disease diagnostics. Genome Medicine. 14(1):Article 38. https://doi.org/10.1186/s13073-022-01019-9

Wen B, Tang S, Lv X, Li D, Xu J, Olsen RKJ, Zhao Y, Li W, Wang T, Shao K, et al. 2022. Clinical, pathological and genetic features and follow-up of 110 patients with late-onset MADD: A single-center retrospective study. Human Molecular Genetics. 31(7):1115-1129. https://doi.org/10.1093/hmg/ddab308

Fruekilde SK , Bailey CJ, Lambertsen KL, Clausen BH, Carlsen J, Xu NL, Drasbek KR , Gutiérrez-Jiménez E. 2022. Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation. Journal of Cerebral Blood Flow and Metabolism. 42(12):2303-2317. https://doi.org/10.1177/0271678X221112278

Moeslund N, Long Zhang Z, Bo Ilkjaer L , Ryhammer PK, Cramer C, Palmfeldt J , Pedersen M, Erasmus ME, Tsui S, Eiskjaer H. 2022. High Oxygenation During Normothermic Regional Perfusion After Circulatory Death Is Beneficial on Donor Cardiac Function in a Porcine Model. Transplantation. 106(7):e326-e335. https://doi.org/10.1097/TP.0000000000004164

Furuya H, Sasaki Y, Chen R, Peres R, Hokutan K, Murakami K, Kim N, Chan OTM, Pagano I, Dyrskjøt L, et al. 2022. PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity. Scientific Reports. 12(1):Article 12186. https://doi.org/10.1038/s41598-022-16518-3

Carlsen J , Gutiérrez-Jiménez E , Østergaard L , Palmfeldt J. 2022. Proteomes of the TG-SWDI Murine Model of Alzheimer's disease. Poster session presented at Danish Proteomics Society (DAPSOC) Symposium, Odense, Denmark.

Sellmer A , Henriksen TB , Palmfeldt J , Bech BH , Astono J, Bennike TB, Hjortdal VE. 2022. The Patent Ductus Arteriosus in Extremely Preterm Neonates Is More than a Hemodynamic Challenge: New Molecular Insights. Biomolecules. 12(9):Article 1179. https://doi.org/10.3390/biom12091179

Paternoster V , Cömert C , Kirk LS , la Cour SH , Fryland T , Fernandez-Guerra P , Stougaard M , Nyengaard JR , Qvist P , Bross P, et al. 2022. The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation. Translational Psychiatry. 12(1):Article 319. https://doi.org/10.1038/s41398-022-02053-2

Login FH , Palmfeldt J, Cheah J, Yamada S, Nejsum LN. 2021. Aquaporin-5 regulation of cell-cell adhesion proteins: an elusive "tail" story. American Journal of Physiology: Cell Physiology. 320(3):C282-C292. https://doi.org/10.1152/ajpcell.00496.2020

Märcher A , Palmfeldt J , Nisavic M , Gothelf KV. 2021. A Reagent for Amine-Directed Conjugation to IgG1 Antibodies. Angewandte Chemie International Edition. 60(12):6539-6544. https://doi.org/10.1002/anie.202013911

Djernis D, OToole MS , Fjorback LO, Svenningsen H, Mehlsen MY, Stigsdottir U, Dahlgaard J. 2021. A Short Mindfulness Retreat for Students to Reduce Stress and Promote Self-Compassion: Pilot Randomised Controlled Trial Exploring Both an Indoor and a Natural Outdoor Retreat Setting. Healthcare (Basel, Switzerland). 9(7):Article 910. https://doi.org/10.3390/healthcare9070910

Lund M , Andersen KG, Heaton R, Hargreaves IP, Gregersen N , Olsen RKJ. 2021. Bezafibrate activation of PPAR drives disturbances in mitochondrial redox bioenergetics and decreases the viability of cells from patients with VLCAD deficiency. B B A - Molecular Basis of Disease. 1867(6):Article 166100. https://doi.org/10.1016/j.bbadis.2021.166100

Fernandez-Guerra P, Gonzalez-Ebsen AC, Boonen SE, Courraud J, Gregersen N , Mehlsen J , Palmfeldt J , Olsen RKJ, Brinth LS. 2021. Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory Study. Biomolecules. 11(7):Article 961. https://doi.org/10.3390/biom11070961

Henriques BJ, Katrine Jentoft Olsen R, Gomes CM, Bross P. 2021. Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease. Gene. 776:Article 145407. https://doi.org/10.1016/j.gene.2021.145407

Farup J , Just J , de Paoli F , Lin L , Jensen JB , Billeskov T , Roman IS , Cömert C , Møller AB, Madaro L, et al. 2021. Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients. Cell Metabolism. 33(11):2201-2214.e10. https://doi.org/10.1016/j.cmet.2021.10.001

Paternoster V , Edhager AV , Qvist P , Donskov JG, Shliaha P, Jensen ON, Mors O , Nielsen AL , Børglum AD , Palmfeldt J, et al. 2021. Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping. Molecular Neurobiology. 58(9):4495-4505. https://doi.org/10.1007/s12035-021-02432-8

Al-Mashhadi RH , Al-Mashhadi AL , Nasr ZP , Mortensen MB, Lewis EA, Camafeita E, Ravlo K , Al-Mashhadi Z , Kjær DW , Palmfeldt J, et al. 2021. Local Pressure Drives Low-Density Lipoprotein Accumulation and Coronary Atherosclerosis in Hypertensive Minipigs. Journal of the American College of Cardiology. 77(5):575-589. https://doi.org/10.1016/j.jacc.2020.11.059

Lund AM, Wibrand F, Skogstrand K, Bækvad-Hansen M, Gregersen N, Andresen BS, Hougaard DM, Dunø M, Olsen RKJ. 2021. Use of molecular genetic analyses in danish routine newborn screening. International Journal of Neonatal Screening. 7(3):Article 50. https://doi.org/10.3390/IJNS7030050

Fogh S , Dipace G , Bie A, Veiga-da-Cunha M, Hansen J , Kjeldsen M , Mosegaard S, Ribes A, Gregersen N , Aagaard L, et al. 2021. Variants in the Ethylmalonyl-CoA Decarboxylase (ECHDC1) Gene; a Novel Player in Ethylmalonic Aciduria?. Journal of Inherited Metabolic Disease. 44(5):1215-1225. https://doi.org/10.1002/jimd.12394

Bie AS , Cömert C, Körner R, Corydon TJ , Palmfeldt J, Hipp MS, Hartl FU, Bross P. 2020. An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space. Cell Stress & Chaperones. 25(3):407-416. https://doi.org/10.1007/s12192-020-01080-6

Cömert C, Brick L, Ang D, Palmfeldt J, Meaney BF, Kozenko M, Georgopoulos C, Fernandez-Guerra P , Bross P. 2020. A recurrent de novo HSPD1 variant is associated with hypomyelinating leukodystrophy. Cold Spring Harbor molecular case studies. 6(3):Article a004879. https://doi.org/10.1101/mcs.a004879

Hollensen AK , Thomsen HS , Lloret-Llinares M , Kamstrup AB , Jensen JM , Luckmann M , Birkmose N , Palmfeldt J , Jensen TH , Hansen TB, et al. 2020. circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation. eLife. 9:1-29. https://doi.org/10.7554/eLife.58478

Lund A, Wibrand F, Skogstrand K, Cohen A, Christensen M, Jäpelt RB, Dunø M, Skovby F, Nørgaard-Pedersen B, Gregersen N, et al. 2020. Danish expanded newborn screening is a successful preventive public health programme. Danish Medical Journal. 67(1):Article A06190341.

Schou AS, Nielsen JE, Askeland A, Jørgensen MM. 2020. Extracellular vesicle-associated proteins as potential biomarkers. Makowski GS, editor. In Advances in Clinical Chemistry. Elsevier. pp. 1-48. https://doi.org/10.1016/bs.acc.2020.02.011

Laustsen C , Nielsen PM , Qi H , Løbner MH , Palmfeldt J , Bertelsen LB. 2020. Hyperpolarized [1,4-¹³C]fumarate imaging detects microvascular complications and hypoxia mediated cell death in diabetic nephropathy. Scientific Reports. 10:Article 9650. https://doi.org/10.1038/s41598-020-66265-6

Nochi Z , Birkler RID , Fernandez-Guerra P , Hansen J, Wibrand F, Corydon TJ , Gregersen N , Olsen RKJ. 2020. Increased antioxidant response in medium-chain acyl-CoA dehydrogenase deficiency: does lipoic acid have a protective role?. Pediatric Research. 88(4):556-564. https://doi.org/10.1038/s41390-020-0801-1

Mortensen MR , Skovsgaard MB , Märcher A , Andersen VL , Palmfeldt J , Nielsen TB , Tørring T , Laursen NS , Andersen KR , Kjems J, et al. 2020. Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling. Bioconjugate Chemistry. 31(5):1295-1300. https://doi.org/10.1021/acs.bioconjchem.0c00151

Groennebaek T , Billeskov TB , Schytz CT , Jespersen NR , Bøtker HE , Olsen RKJ, Eldrup N, Nielsen J, Farup J , De Paoli FV, et al. 2020. Mitochondrial Structure and Function in the Metabolic Myopathy Accompanying Patients with Critical Limb Ischemia. Cells. 9(3):Article 570. https://doi.org/10.3390/cells9030570

Carlsen J , Cömert C , Bross P , Palmfeldt J. 2020. Optimized High-Contrast Brightfield Microscopy Application for Noninvasive Proliferation Assays of Human Cell Cultures. ASSAY and Drug Development Technologies. 18(5):215-225. https://doi.org/10.1089/adt.2020.981

Ribeiro JV, Lucas TG, Bross P, Gomes CM, Henriques BJ. 2020. Potential complementation effects of two disease-associated mutations in tetrameric glutaryl-CoA dehydrogenase is due to inter subunit stability-activity counterbalance. B B A - Proteins and Proteomics. 1868(1):Article 140269. https://doi.org/10.1016/j.bbapap.2019.140269

Rajkumar AP , Qvist P , Donskov JG, Lazarus R, Pallesen J , Nava N , Winther G , Liebenberg N , Cour SHL , Paternoster V, et al. 2020. Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice. Translational Psychiatry. 10:Article 239. https://doi.org/10.1038/s41398-020-00914-2

Mosegaard S , Dipace G , Bross P , Carlsen J , Gregersen N , Olsen RKJ. 2020. Riboflavin deficiency—implications for general human health and inborn errors of metabolism. International Journal of Molecular Sciences . 21(11):Article 3847. https://doi.org/10.3390/ijms21113847

Ketheeswaran S , Alsbjerg B, Christensen P, Gravholt CH , Humaidan P. 2019. 45,X/46,XY Mosaicism and Normozoospermia in a Patient with Male Phenotype. Case reports in medicine. 2019:Article 2529080. https://doi.org/10.1155/2019/2529080

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