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Department of Clinical Medicine

Research Unit for Molecular Medicine (MMF)

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Gutiérrez-Jiménez E , Rasmussen PM , Mikkelsen IK, Kura S, Fruekilde SK , Hansen B, Bordoni L, Carlsen J , Palmfeldt J , Boas DA, et al. 2025. Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis. Alzheimer's & Dementia. 21(3):Article e70023. https://doi.org/10.1002/alz.70023

Chang S , Pedersen L , Skakkebæk A , Berglund A , Gravholt CH. 2025. Cardiovascular risk and mortality in men receiving testosterone replacement therapy for Klinefelter syndrome in Denmark: a retrospective cohort study. The Lancet Regional Health - Europe. 51:Article 101230. https://doi.org/10.1016/j.lanepe.2025.101230

Carlsen J, Fossati S, Østergaard L , Gutiérrez-Jiménez E , Palmfeldt J. 2025. Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors. Alzheimer's and Dementia. 21(4):Article e70122. https://doi.org/10.1002/alz.70122

Just J , Ridder LOR , Johannsen EB , Jensen JMB , Petersen MS , Christensen HV, Kjærgaard K, Redder J, Chang S , Stochholm K, et al. 2025. Elevated levels of neutrophils with a pro-inflammatory profile in Turner syndrome across karyotypes. npj Genomic Medicine. 10(1):Article 9. https://doi.org/10.1038/s41525-025-00467-7

Hansen KS , Jørgensen SE , Cömert C , Schiøttz-Christensen B , Bross P , Agergaard J , Leth S , Østergaard L , Palmfeldt J , Olsen RKJ, et al. 2025. Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID. Journal of Medical Virology. 97(3):Article e70275. https://doi.org/10.1002/jmv.70275

Kapel JS, Stokholm R, Elmengaard B , Nochi Z , Olsen RJ, Foldager CB. 2025. Individualized Algorithm-Based Intermittent Hypoxia Improves Quality of Life in Patients Suffering from Long-Term Sequelae After COVID-19 Infection. Journal of Clinical Medicine. 14(5):Article 1590. https://doi.org/10.3390/jcm14051590

Palmfeldt J. 2025. Interaction and regulation of the mitochondrial proteome - in health and disease. Expert Review of Proteomics. 22(1):19-33. https://doi.org/10.1080/14789450.2025.2451704

on behalf of Danish Thyroid Cancer Group (DATHYRCA). 2025. RET C611Y Germline Variant in Multiple Endocrine Neoplasia Type 2A in Denmark 1930–2021: A Nationwide Study. Cancers. 17(3):Article 374. https://doi.org/10.3390/cancers17030374

Dittrich A , Andersson SA , Busk M , Hansen K , Foldager CB , Palmfeldt J , Andersen A , Pedersen M , Vendelbo M , Nielsen KL, et al. 2025. Metabolic changes during cardiac regeneration in the axolotl. Developmental Dynamics. https://doi.org/10.1002/dvdy.70020

Woytash JA, Kumar R, Chaudhary AK, Donnelly C, Wojtulski A, Bethu M, Wang J, Spernyak J, Bross P, Yadav N, et al. 2025. Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer. Oncogene. 44(12):820-834. https://doi.org/10.1038/s41388-024-03261-4

Leunbach TL , Berglund A , Ernst A , Hvistendahl GM , Rawashdeh YF , Gravholt CH. 2025. Prevalence, Incidence, and Age at Diagnosis of Boys With Hypospadias: A Nationwide Population-Based Epidemiological Study. Journal of Urology. 213(3):350-358. https://doi.org/10.1097/JU.0000000000004319

Biswas D, Liu YH, Herrero J, Wu Y, Moore DA, Karasaki T, Grigoriadis K, Lu WT, Veeriah S, Naceur-Lombardelli C, et al. 2025. Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma. Nature Cancer. 6(1):86-101. https://doi.org/10.1038/s43018-024-00883-1

Elbæk SK , Lamy P, Laugesen S, Stilling C , Nordentoft I , Dyrskjøt L , Jakobsen JK. 2025. Retrospective clinical and molecular characterisation of patients with penile intraepithelial neoplasia. BJU International. https://doi.org/10.1111/bju.16754

Simonsen MR, Jensen JF, Larsen TS, Gade IL, de Nully Brown P, El-Galaly TC. 2025. The Prevalence of Diffuse Large B-Cell Lymphoma Varies Substantially by Methods Applied: Results From a Population-Based Study. European Journal of Haematology. 114(3):528-535. https://doi.org/10.1111/ejh.14359

Frydendahl A, Widman AJ, Øgaard N, Arora A, Halmos D, Nors J , Ahrenfeldt J , Henriksen TV , Demuth C , Raaby L, et al. 2025. Whole-genome sequencing of cell-free DNA reveals DNA of tumor origin in plasma from patients with colorectal adenomas. Molecular Oncology. 19(4):984-993. https://doi.org/10.1002/1878-0261.13803

Eg Gadegaard IS, Eskildsen MH, Østergaard SK, Nielsen JL, Rasmussen JT. 2025. Xanthine oxidase-lactoperoxidase system: Dose-dependent antibacterial effects and global gene expression changes in infant oral microbiota. Food Research International. 201:Article 115596. https://doi.org/10.1016/j.foodres.2024.115596

Bertelsen MB , Tsang E , Palmfeldt J, Kristoffersen CH, Nisavic M , Gothelf KV. 2024. A Diketopinic Reagent for the Reversible Bioconjugation to Arginine Residues on Native Antibodies. Bioconjugate Chemistry. 35(11):1755-1761. https://doi.org/10.1021/acs.bioconjchem.4c00317

Razim A, Zabłocka A, Schmid A, Thaler M, Černý V, Weinmayer T, Whitehead B, Martens A, Skalska M, Morandi M, et al. 2024. Bacterial extracellular vesicles as intranasal postbiotics: Detailed characterization and interaction with airway cells. Journal of Extracellular Vesicles. 13(10):Article e70004. https://doi.org/10.1002/jev2.70004

Lin Y , Rasmussen MH , Christensen MH , Frydendahl A, Maretty L, Andersen CL , Besenbacher S. 2024. Evaluating Bioinformatics Processing of Somatic Variant Detection in cfDNA Using Targeted Sequencing with UMIs. International Journal of Molecular Sciences . 25(21):Article 11439. https://doi.org/10.3390/ijms252111439

Steininger F , Palmfeldt J , Koren K , Kalinichev AV. 2024. Exploiting the pH-Cross Sensitivity of Ion-Selective Optodes to Broaden Their Response Range. ACS Sensors. 9(9):4555-4559. https://doi.org/10.1021/acssensors.4c01481

Eskin-Schwartz M, Seraidy S, Paz E, Molhem M, Ranza E, Antonarakis SE, Blanc X, Herman K, Benko WS, Libzon S, et al. 2024. Heterozygous de novo variants in HSPD1 cause hypomyelinating leukodystrophy through impaired HSP60 oligomerisation. Journal of Medical Genetics. 62(1):15-24. https://doi.org/10.1136/jmg-2024-109862

Cömert C , Kjær-Sørensen K , Hansen J , Carlsen J , Just J, Meaney BF, Østergaard E, Luo Y , Oxvig C , Schmidt-Laursen L, et al. 2024. HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis. Molecular Metabolism. 88:Article 102009. https://doi.org/10.1016/j.molmet.2024.102009

Mosegaard S , Twayana KS, Denis SW, Kroon J, Schomakers BV, van Weeghel M, Houtkooper RH, Olsen RKJ , Holm CK. 2024. Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS. FASEB BioAdvances. 6(9):337-350. https://doi.org/10.1096/fba.2024-00060

Johannessen AL , Alstrup M , Hjortdal VE , Palmfeldt J , Offersen BV , Mohanakumar S. 2024. Increased Microvascular Filtration and Vascular Endothelial Growth Factor-D associated with Changed Lymphatic Vessel Morphology in Breast Cancer Treated Patients. Plastic and Reconstructive Surgery - Global Open. 12(7):Article e5968. https://doi.org/10.1097/GOX.0000000000005968

Berglund A , Johannsen EB , Skakkebæk A , Chang S, Rohayem J, Laurentino S, Hørlyck A , Drue SO , Bak EN, Fedder J, et al. 2024. Integration of long-read sequencing, DNA methylation and gene expression reveals heterogeneity in Y chromosome segment lengths in phenotypic males with 46,XX testicular disorder/difference of sex development. Biology of Sex Differences. 15(1):Article 77. https://doi.org/10.1186/s13293-024-00654-8

Øzdemir CM, Nielsen MM, Liimatta J, Voegel CD, Elzenaty RN, Wasehuus VS, Lind-Holst M , Ornstrup MJ, Gram SB, Ousager LB, et al. 2024. Late diagnosis of partial 3β-hydroxysteroid dehydrogenase type 2 deficiency – characterization of a new genetic variant. Endocrinology, Diabetes and Metabolism Case Reports. 2024(3):Article 23-0090. https://doi.org/10.1530/EDM-23-0090

Hasselholt S , Cömert C , Just J , Bross P , Nyengaard JR , Hansen B , Østergaard L. 2024. Microvessel and mitochondria changes in a mouse model of Alzheimer’s disease. BIO Web of Conferences. 129:Article 16017. https://doi.org/10.1051/bioconf/202412916017

Atay JCL , Elsborg SH , Palmfeldt J , Nejsum LN , Nørregaard R. 2024. Recovery of Water Homeostasis in Adenine-Induced Kidney Disease Is Mediated by Increased AQP2 Membrane Targeting. International Journal of Molecular Sciences (Online). 25(6):Article 3447. https://doi.org/10.3390/ijms25063447

Eggertsen PP , Palmfeldt J, Schytz HW, Hay D, Olsen RKJ , Nielsen JF. 2024. Serum calcitonin gene‑related peptide in patients with persistent post‑concussion symptoms, including headache: a cohort study. Journal of Neurology. 271(5):2458-2472. https://doi.org/10.1007/s00415-024-12181-y

Eggertsen PP , Palmfeldt J , Pedersen AR , Frederiksen O-V , Olsen RKJ , Nielsen JF. 2024. Serum neurofilament light chain, inflammatory markers, and kynurenine metabolites in patients with persistent post-concussion symptoms: A cohort study. Journal of the Neurological Sciences. 460:Article 123016. https://doi.org/10.1016/j.jns.2024.123016

Fahlquist-Hagert C , Wittenborn TR , Terczyńska-Dyla E , Kastberg KS, Yang E, Rallistan AN, Markett QR, Winther G , Fonager S , Voss LF, et al. 2023. Antigen presentation by B cells enables epitope spreading across an MHC barrier. Nature Communications. 14(1):Article 6941. https://doi.org/10.1038/s41467-023-42541-7

Ghavami M, Pedersen JG, Kjeldsen RB, Alstrup AKO, Zhang Z, Koulianou V, Palmfeldt J , Vorup-Jensen T, Thamdrup LHE, Boisen A. 2023. A self-unfolding proximity enabling device for oral delivery of macromolecules. Journal of Controlled Release. 361:40-52. https://doi.org/10.1016/j.jconrel.2023.07.041

Frandsen M , El-Chami K , Palmfeldt J , Smidt JM , Langballe MET , Sandahl A , Gothelf KV. 2023. Automated Solid-Phase Oligo(disulfide) Synthesis. Angewandte Chemie International Edition. 62(23):Article e202303170. https://doi.org/10.1002/anie.202303170

Moeslund N, Zhang ZL, Dalsgaard FF , Glenting SB , Ilkjaer LB , Ryhammer P , Palmfeldt J , Pedersen M, Erasmus M, Eiskjaer H. 2023. Clamping of the Aortic Arch Vessels During Normothermic Regional Perfusion Does Not Negatively Affect Donor Cardiac Function in Donation After Circulatory Death. Transplantation. 107(1):E3-E10. https://doi.org/10.1097/TP.0000000000004298

Jørgensen CS , Kamperis K , Knudsen JH , Kjeldsen M , Christensen JH , Borch L , Rittig S , Palmfeldt J. 2023. Differences in the urinary metabolome and proteome between wet and dry nights in children with monosymptomatic nocturnal enuresis and nocturnal polyuria. Pediatric nephrology (Berlin, Germany). 38(10):3347-3358. https://doi.org/10.1007/s00467-023-05963-5

Skakkebæk A , Kjær-Sørensen K , Matchkov VV , Christensen LL , Just J , Cömert C, Andersen NH, Oxvig C , Gravholt CH. 2023. Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration. Scientific Reports. 13(1):Article 12089. https://doi.org/10.1038/s41598-023-38867-3

Schmid AM, Razim A, Wysmołek M, Kerekes D, Haunstetter M, Kohl P, Brazhnikov G, Geissler N, Thaler M, Krčmářová E, et al. 2023. Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice. Cell Communication and Signaling. 21(1):Article 297. https://doi.org/10.1186/s12964-023-01329-4

Agergaard J , Yamin Ali Khan B , Engell-Sørensen T, Schiøttz-Christensen B, Jørgen Østergaard L, Hejbøl EK, Schrøder HD, Andersen H, Blicher JU, Holm Pedersen T, et al. 2023. Myopathy as a cause of Long COVID fatigue: Evidence from quantitative and single fiber EMG and muscle histopathology. Clinical Neurophysiology. 148:65-75. https://doi.org/10.1016/j.clinph.2023.01.010

Jeppesen LD , Lildballe DL , Hatt L , Hedegaard J , Singh R, Toft CLF, Schelde P, Pedersen AS , Knudsen M , Vogel I. 2023. Noninvasive Prenatal Screening for Cystic Fibrosis Using Circulating Trophoblasts: Detection of the 50 Most Common Disease-Causing Variants. Obstetrical and Gynecological Survey. 78(7):393-395. https://doi.org/10.1097/01.ogx.0000947140.57660.b6

Lund M, Heaton R, Hargreaves IP, Gregersen N , Olsen RKJ. 2023. Odd- and even-numbered medium-chained fatty acids protect against glutathione depletion in very long-chain acyl-CoA dehydrogenase deficiency. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1868(2):Article 159248. https://doi.org/10.1016/j.bbalip.2022.159248

Nisavic M , Wørmer GJ , Nielsen CS, Jeppesen SM, Palmfeldt J , Poulsen TB. 2023. oxSTEF Reagents Are Tunable and Versatile Electrophiles for Selective Disulfide-Rebridging of Native Proteins. Bioconjugate Chemistry. 34(6):994-1003. https://doi.org/10.1021/acs.bioconjchem.3c00005

Eggertsen PP , Hansen J , Andersen ML , Nielsen JF , Olsen RKJ , Palmfeldt J. 2023. Simultaneous measurement of kynurenine metabolites and explorative metabolomics using liquid chromatography-mass spectrometry: A novel accurate method applied to serum and plasma samples from a large healthy cohort. Journal of Pharmaceutical and Biomedical Analysis. 227:Article 115304. https://doi.org/10.1016/j.jpba.2023.115304

Curnock R, Yalci K, Palmfeldt J, Jäättelä M, Liu B, Carroll B. 2023. TFEB-dependent lysosome biogenesis is required for senescence. The EMBO Journal. 42(9):e111241. https://doi.org/10.15252/embj.2022111241

Mahía A , Kiib AE , Nisavic M , Svenningsen EB , Palmfeldt J , Poulsen TB. 2023. α-Lactam Electrophiles for Covalent Chemical Biology. Angewandte Chemie - International Edition. 62(26):Article e202304142. https://doi.org/10.1002/anie.202304142

Wu A, Wolley MJ, Wu Q, Cowley D, Palmfeldt J, Welling PA, Fenton RA, Stowasser M. 2022. Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles. Kidney360. 3(5):910-921. https://doi.org/10.34067/KID.0000362022

Ipsen MB , Sørensen EMG , Thomsen EA , Weiss S , Haldrup J , Dalby A , Palmfeldt J , Bross P , Rasmussen M , Fredsøe J, et al. 2022. A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer. Oncogene. 41(37):4271-4281. https://doi.org/10.1038/s41388-022-02427-2

Dinesen A , Winther A, Wall A, Märcher A , Palmfeldt J, Chudasama V, Wengel J, Gothelf KV, Baker JR, Howard KA. 2022. Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly. Bioconjugate Chemistry. 33(2):333-342. https://doi.org/10.1021/acs.bioconjchem.1c00561

Dinesen A , Winther A, Wall A, Märcher A , Palmfeldt J, Chudasama V, Wengel J, Gothelf KV, Baker JR, Howard K. 2022. An Albumin Biomolecular Drug Design Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Assembly. Poster session presented at Controlled Release Society 2022 Annual Meeting, Montreal, Quebec, Canada.

Sabaratnam R, Skov V, Paulsen SK, Juhl S, Kruse R, Hansen T, Halkier C, Kristensen JM, Vind BF, Richelsen B, et al. 2022. A Signature of Exaggerated Adipose Tissue Dysfunction in Type 2 Diabetes Is Linked to Low Plasma Adiponectin and Increased Transcriptional Activation of Proteasomal Degradation in Muscle. Cells. 11(13):Article 2005. https://doi.org/10.3390/cells11132005

Gögenur M, Lindbjerg Andersen C, Gögenur I. 2022. ASO Author Reflections: Is ctDNA Detection an Accurate Measure of the Risk of Recurrence in Patients Undergoing Neoadjuvant Treatment?. Annals of Surgical Oncology. 29(13):8675. https://doi.org/10.1245/s10434-022-12378-3

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Helle Just