HESMEGLE WP ll

Title: PENIMA – Penile Imaging

PENIMA is a part of the project HESMEGLE (Health Care Seeking Exploration and Intelligent Morphology Regocnition to Obtain Coherent Patient Trajectory in Men with Genital Lesions) and is the working title for Work Package II (WP II). HESMEGLE is a larger project in collaboration with The Research Unit for General Practice at Copenhagen University with a common focus on improvement of the patient trajectory for men with genital lesions.

Aim: In WP II, PENIMA, we aim to develop an image recognition software as an explainable artificial intelligence (AI) based decision-supporting tool for health professionals evaluating penile lesions. The ambition is that this tool could catalyze a new and optimized patient trajectory in men with penile lesions. We plan to develop the AI using digital images of genital lesions and their clinical course. The AI will be available to health care professionals for assistance in recognizing rare changes, biopsy strategies and the need to refer the patient to the right treatment at the correct health care site. It will not become a diagnostic tool, but a decision support tool.

Methods: HESMEGLE WP II is carried out as a clinical prospective data acquisition study in dermatology and urology university hospital settings. After written consent from participants, digital images will be collected. Images are entered into the artificial intelligence learning platform and retrospectively validated according to histology or clinical course (response to treatment or progression). This will build and reinforce our explainable artificial intelligence-based decision-supporting tool prototype for genital lesions. 

Status: Recruiting, 1247 patients included (summer 2026)

Active Inclusion Sites: multiple sites across Scandinavia

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