Mitochondrial medicine

The mitochondrial functions

One of MMF’s core areas is - and has long been - mitochondrial metabolising of fatty acids. In addition, we research mitochondrial metabolising of the signal gas sulphide and of the branch-chained amino acids, which like the fatty acid metabolising, provide substrates for the citric acid cycle and the respiration process that produces ATP and ROS. Other important mitochondrion functions which are under research are protein quality control (mitochondrion chaperones and proteases), mitochondrion-regulated ROS (Reactive Oxygen Species), antioxidant systems, apoptosis/necrosis as well as metabolic regulation (Warburg effect). The studies are carried out on different forms of specimens, cultivated patient fibroblasts, tissue samples from animal models, blood cells from patients, cell models, etc.