Department of Clinical Medicine

Research Unit for Molecular Medicine (MMF)

 Department of Clinical Medicine MMF Publications

Publications

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Hansen J, Bross P. 2010. A cellular viability assay to monitor drug toxicity. Methods in molecular biology (Clifton, N.J.). 648:303-11. https://doi.org/10.1007/978-1-60761-756-3_21
Piekutowska-Abramczuk D, Olsen RKJ, Wierzba J, Popowska E, Jurkiewicz D, Ciara E, Ołtarzewski M, Gradowska W, Sykut-Cegielska J, Krajewska-Walasek M, et al. 2010. A comprehensive HADHA c.1528G>C frequency study reveals high prevalence of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency in Poland. Journal of Inherited Metabolic Disease. https://doi.org/10.1007/s10545-010-9190-7
Piekutowska-Abramczuk D, Olsen R, Wierzba J, Popowska E, Jurkiewicz D, Ciara E, Ołtarzewski M, Gradowska W, Sykut-Cegielska J, Krajewska-Walasek M, et al. 2010. A comprehensive HADHA c.1528G>C frequency studyreveals high prevalence of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency in Poland. Journal of Inherited Metabolic Disease.
Dessein A-F, Fontaine M, Andresen BS, Gregersen N, Brivet M, Rabier D, Napuri-Gouel S, Dobbelaere D, Mention-Mulliez K, Martin-Ponthieu A, et al. 2010. A novel mutation of the ACADM gene (c.145C>G) associated with the common c.985A>G mutation on the other ACADM allele causes mild MCAD deficiency: a case report. Orphanet Journal of Rare Diseases. 5:26. https://doi.org/10.1186/1750-1172-5-26
Singh R, Kølvraa S, Bross PG, Christensen K, Bathum L, Gregersen N, Tan Q, Rattan S. 2010. Anti-inflammatory heat shock protein 70 genes are positively associated with human survival. Current Pharmaceutical Design. 16(7):796-801.
Pedersen CB, Zolkipli Z, Vang S, Palmfeldt J, Kjeldsen M, Stenbroen V, Schmidt S, Wanders RJA, Ruiter JPN, Wibrand F, et al. 2010. Antioxidant dysfunction: potential risk for neurotoxicity in ethylmalonic aciduria. Journal of Inherited Metabolic Disease. 33(3):211-22. https://doi.org/10.1007/s10545-010-9086-6
Birkler RID, Støttrup N, Hermannson S, Nielsen TT, Gregersen N, Bøtker HE, Andreasen MF, Johannsen M. 2010. A UPLC-MS/MS application for profiling of intermediary energy metabolites in microdialysis samples--a method for high-throughput. Journal of Pharmaceutical and Biomedical Analysis. 53(4):983-90. https://doi.org/10.1016/j.jpba.2010.06.005
Palmfeldt J, Stenbroen V, Vang S, Gregersen N. 2010. CHARACTERIZATION OF THE MITOCHONDRIAL PROTEOME IN CULTIVATED CELLS FROM PATIENTS SUFFERING FROM ETHYLMALONIC ENCEPHALOPATHY. Molecular Genetics and Metabolism. (1).
Gregersen N, Olsen RKJ. 2010. Disease mechanisms and protein structures in fatty acid oxidation defects. Journal of Inherited Metabolic Disease. https://doi.org/10.1007/s10545-010-9046-1
Henriques BJ, Olsen RK, Bross P, Gomes CM. 2010. Emerging roles for riboflavin in functional rescue of mitochondrial β-oxidation flavoenzymes. Current Medicinal Chemistry. 17(32):3842-54.
Olsen R, Dobrowolski SF, Kjeldsen M, Hougaard D, Simonsen H, Gregersen N, Andresen BS. 2010. High-resolution melting analysis, a simple and effective method for reliable mutation scanning and frequency studies in the ACADVL gene. Journal of Inherited Metabolic Disease. 33:247-60.
Olsen RKJ, Dobrowolski SF, Kjeldsen M, Hougaard D, Simonsen H, Gregersen N, Andresen BS. 2010. High-resolution melting analysis, a simple and effective method for reliable mutation scanning and frequency studies in the ACADVL gene. Journal of Inherited Metabolic Disease. 33(3):247-60. https://doi.org/10.1007/s10545-010-9101-y
Madsen PP. 2010. Identification and characterization of prognostic and predictive markers in bladder cancer. Aarhus Universitet.
Christensen JH, Nielsen MN, Hansen J, Füchtbauer A, Füchtbauer E-M, West M, Corydon TJ, Gregersen N, Bross P. 2010. Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice. Cell Stress & Chaperones. 15(6):851-863. https://doi.org/10.1007/s12192-010-0194-x
Schmidt S. 2010. Investigation of a Misfolded Mitochondrial Protein - The cellular handling of a disease-accociated variant of short-chain acyl-CoA dehydrogenase (SCAD). Aarhus Universitet.
Baiges I, Palmfeldt J, Blade C, Gregersen N, Arola L. 2010. Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet. Molecular and Cellular Proteomics. https://doi.org/10.1074/mcp.M000055-MCP201
Bross P, Palmfeldt J, Hansen J, Vang S, Gregersen N. 2010. Measuring Consequences of Protein Misfolding and Cellular Stress Using OMICS Techniques. Methods in Molecular Biology. 648:119-35. https://doi.org/10.1007/978-1-60761-756-3_8
Straadt IK, Young JF, Petersen BO, Duus JØ, Gregersen N, Bross P, Oksbjerg N, Bertram HC. 2010. Metabolic profiling of heat or anoxic stress in mouse C2C12 myotubes using multinuclear magnetic resonance spectroscopy. Metabolism. 59(6):814-823. https://doi.org/10.1016/j.metabol.2009.09.029
Schmidt S, Corydon TJ, Pedersen CB, Bross P, Gregersen N. 2010. Misfolding of short-chain acyl-CoA dehydrogenase leads to mitochondrial fission and oxidative stress. Molecular Genetics and Metabolism. 100(2):155-162.
Henriques BJ, Bross P, Gomes CM. 2010. Mutational hotspots in electron transfer flavoprotein underlie defective folding and function in multiple acyl-CoA dehydrogenase deficiency. BBA General Subjects. https://doi.org/10.1016/j.bbadis.2010.07.015
Straadt IK, Young JF, Bross P, Gregersen N, Oksbjerg N, Theil PK, Bertram HC. 2010. NMR-Based Metabonomic Investigation of Heat Stress in Myotubes Reveals a Time-Dependent Change in the Metabolites. Journal of Agricultural and Food Chemistry. 58:6376-6386. https://doi.org/10.1021/jf904197u
Straadt IK, Young JF, Petersen BO, Duus JØ, Gregersen N, Bross P, Oksbjerg N, Theil PK, Bertram HC. 2010. Oxidative stress-induced metabolic changes in mouse C2C12 myotubes studied with high-resolution 13C, 1H, and 31P NMR spectroscopy. Journal of Agricultural and Food Chemistry. 58(3):1918-26. https://doi.org/10.1021/jf903505a
Hansen J, Lesnikova I, Lundemose JB. 2010. PCR-based quality evaluation of DNA extracted from autopsy tissue material archived at department of Forensic Medicine Aarhus University. Poster session presented at Årsmøde i Dansk Selskab for Retsmedicin, Odense, Denmark.
Hansen J, Lesnikova I, Lundemose JB. 2010. PCR-based quality evaluation of DNA extracted from autopsy tissue material archived at department of Forensic Medicine Aarhus University. Abstract from Årsmøde i Dansk Selskab for Retsmedicin, Odense, Denmark.
Gregersen N, Bross P. 2010. Protein misfolding and cellular stress: an overview. Methods in Molecular Biology. 648:3-23. https://doi.org/10.1007/978-1-60761-756-3_1
Pedersen CB, Gregersen N. 2010. Stress response profiles in human fibroblasts exposed to heat shock or oxidative stress. Methods in Molecular Biology. 648.
Sykut-Cegielska J, Gradowska W, Piekutowska-Abramczuk D, Andresen BS, Olsen R, Ołtarzewski M, Pronicki M, Pajdowska M, Bogdańska A, Jabłońska E, et al. 2010. Urgent metabolic service improves survival in long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency detected by symptomatic identification and pilot newborn screening. Journal of Inherited Metabolic Disease. 34/1(185-95).
Li J, Zhang Z, Vang S, Yu J, Wong GK-S, Wang J. 2009. Correlation between Ka/Ks and Ks is related to substitution model and evolutionary lineage. Journal of Molecular Evolution. 68(4):414-23. https://doi.org/10.1007/s00239-009-9222-9
Faerch M, Christensen JH, Rittig S, Johansson J-O, Gregersen N, de Zegher F, Corydon TJ. 2009. Diverse vasopressin V2 receptor functionality underlying partial congenital nephrogenic diabetes insipidus. American Journal of Physiology: Renal Physiology. 297(6):F1518-25. https://doi.org/10.1152/ajprenal.00331.2009
Egerod FL, Bartels A, Fristrup N, Borre M, Ørntoft TF, Oleksiewicz MB, Brünner N, Dyrskjøt L. 2009. High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression. B M C Cancer. 9:385. https://doi.org/10.1186/1471-2407-9-385
Ostenfeld MS, Bramsen JB, Lamy P, Villadsen SB, Fristrup N, Ulhøi BP, Borre M, Kjems J, Dyrskjøt L, Ørntoft TF. 2009. miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors. Oncogene. https://doi.org/10.1038/onc.2009.395
Gregersen N. 2009. Mitochondrial fatty acid oxidation deficiencies: Remaining challenges. Abstract from Komrower Lecture at Society for the Study of Inborn Errors of Metabolism, Portugal.
Palmfeldt J, Vang S, Stenbroen V, Pedersen CB, Christensen J, Bross P, Gregersen N. 2009. Mitochondrial proteomics on human fibroblasts for identification of metabolic imbalance and cellular stress. Proteome Science. 7(1):20. https://doi.org/10.1186/1477-5956-7-20
Gregersen N. 2009. Nye spørgsmål til kendte sygdomme. AUH.
Henriques BJ, Rodrigues JV, Olsen RK, Bross P, Gomes CM. 2009. Role of flavinylation in a mild variant of multiple acyl-CoA dehydrogenation deficiency: a molecular rationale for the effects of riboflavin supplementation. Journal of Biological Chemistry. 284(7):4222-9. https://doi.org/10.1074/jbc.M805719200
Henriques BJ, Rodrigues JV, Olsen RKJ, Bross PG, Gomes CM. 2009. Role of Flavinylation in a Mild Variant of Multiple Acyl-CoA DehydrogenationDeficiency: A MOLECULAR RATIONALE FOR THE EFFECTS OF RIBOFLAVIN SUPPLEMENTATION. International Journal of Biological Chemistry. 284(7):4222-4229.
Svenstrup K, Bross P, Koefoed P, Hjermind LE, Eiberg H, Born AP, Vissing J, Gyllenborg J, Nørremølle A, Hasholt L, et al. 2009. Sequence variants in SPAST, SPG3A and HSPD1 in hereditary spastic paraplegia. Journal of the Neurological Sciences. 284(1-2):90-5. https://doi.org/10.1016/j.jns.2009.04.024
Gregersen N. 2009.   Skal der screenes for en kontroversiel medfødt stofskiftesygdom. AUH.
Øzbay A, Tørring C, Olsen R, Carstens J. 2009. Transcriptional profiles in urine during acute rejection, bacteriuria, CMV infection and stable graft function after renal transplantation. Scandinavian Journal of Immunology. 69(4):357-65. https://doi.org/10.1111/j.1365-3083.2009.02226.x
Rohde MC, Schmidt S, Corydon TJ, Banner J, Gregersen N. 2008. Cell stress markers in cases of sudden unexpected death in infancy. Abstract from SIDS  10th International Conference 2008, Portsmouth, United Kingdom.
Rohde MC, Schmidt S, Corydon TJ, Banner J, Gregersen N. 2008. Cell stress response in cases of sudden unexpected death in infancy. In Programme and Abstracts from the PhD Day 2008. pp. 147.
Rohde MC, Schmidt S, Banner J, Corydon TJ, Gregersen N. 2008. Cell stress response in cases of sudden unexpected death in infancy. Abstract from PhD Day Aarhus University 2008, Denmark.
Hansen J, Corydon TJ, Palmfeldt J, Dürr A, Fontaine B, Nyholm M, Christensen JH, Gregersen N, Bross P. 2008. Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13). Neuroscience. 153(2):474-82. https://doi.org/10.1016/j.neuroscience.2008.01.070
Xu S, Clark T, Zheng H, Vang S, Li R, Wong G, Wang J, Zheng X. 2008. Gene conversion in the rice genome. BMC Genomics. 9(1):93. https://doi.org/10.1186/1471-2164-9-93
Bak Pedersen C. 2008. Hudceller omdannes til muskelceller - en ny diagnostisk strategi til udredning af muskelrelaterede fedtforbrændingssygdomme. AUH.
Rohde MC, Schmidt S, Banner J, Corydon TJ, Gregersen N. 2008. Hyperthermal cell stress response in cases of sudden infant death. Abstract from International Association of Forensic Sciences 18th triennial meeting, New Orleans, United States.
Cornelius N, Olsen R, Corydon TJ, Gregersen N. 2008. Investigation of the effect of riboflavin on the steady-state amount of variant electron transfer flavoproteins (ETF:QO) identified in patients with riboflavin-responsive multiple acyl-CoA dehydrogeanse deficiency (RR-MADD). Journal of Inherited Metabolic Disease. (1):36.
Gregersen N, Andresen B, Pedersen CB, Olsen R, Corydon T, Bross P. 2008. Mitochondrial fatty acid oxidation defects-remaining challenges. Journal of Inherited Metabolic Disease. https://doi.org/10.1007/s10545-008-0990-y
Magen D, Georgopoulos C, Bross P, Ang D, Segev Y, Goldsher D, Nemirovski A, Shahar E, Ravid S, Luder A, et al. 2008. Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy. American Journal of Human Genetics. 83(1):30-42. https://doi.org/10.1016/j.ajhg.2008.05.016
Færch M, Christensen JH, Corydon TJ, Kamperis K, de Zegher F, Gregersen N, Robertson GL, Rittig S. 2008. Partial nephrogenic diabetes insipidus caused by a novel mutation in the AVPR2 gene. Clinical Endocrinology. 68(3):395-403. https://doi.org/10.1111/j.1365-2265.2007.03054.x

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Helle Just