Publications

The structural heart disease group at Aarhus University and Aarhus University Hospital has a high level of clinical research activity. Here you can see our recent published papers. 

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List of publications

Holmes, D. R., Korsholm, K., Rodés-Cabau, J., Saw, J., Berti, S. & Alkhouli, M. A. (2023). Left atrial appendage occlusion. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 18(13), e1038-e1065. https://doi.org/10.4244/EIJ-D-22-00627
Braams, N. J., Kianzad, A., van Wezenbeek, J., Wessels, J. N., Jansen, S. M. A., Andersen, S., Boonstra, A., Nossent, E. J., Marcus, J. T., Bayoumy, A. A., Becher, C., Goumans, M.-J., Andersen, A., Vonk Noordegraaf, A., de Man, F. S., Bogaard, H. J. & Meijboom, L. J. (2023). Long-Term Effects of Pulmonary Endarterectomy on Right Ventricular Stiffness and Fibrosis in Chronic Thromboembolic Pulmonary Hypertension. Circulation. Heart Failure, 16(10), Article e010336. https://doi.org/10.1161/CIRCHEARTFAILURE.122.010336
Lyhne, M. D., Giordano, N., Dudzinski, D., Torrey, J., Wang, G., Zheng, H., Parry, B. A., Kalra, M. K. & Kabrhel, C. (2023). Low concordance between CTPA and echocardiography in identification of right ventricular strain in PERT patients with acute pulmonary embolism. Emergency Radiology, 30(3), 325-331. https://doi.org/10.1007/s10140-023-02130-z
Lakkireddy, D., Nielsen-Kudsk, J. E., Windecker, S., Thaler, D., Price, M. J., Gambhir, A., Gupta, N., Koulogiannis, K., Marcoff, L., Mediratta, A., Anderson, J. A., Gage, R. & Ellis, C. R. (2023). Mechanisms, predictors, and evolution of severe peri-device leaks with two different left atrial appendage occluders. EP Europace, 25(9). https://doi.org/10.1093/europace/euad237
Alkhouli, M., De Backer, O., Ellis, C. R., Nielsen-Kudsk, J. E., Sievert, H., Natale, A., Lakkireddy, D. & Holmes, D. R. (2023). Peridevice Leak After Left Atrial Appendage Occlusion: Incidence, Mechanisms, Clinical Impact, and Management. JACC. Cardiovascular interventions, 16(6), 627-642. https://doi.org/10.1016/j.jcin.2022.12.006
Mesnier, J., Simard, T., Jung, R. G., Lehenbauer, K. R., Piayda, K., Pracon, R., Jackson, G. G., Flores-Umanzor, E., Faroux, L., Korsholm, K., Chun, J. K. R., Chen, S., Maarse, M., Montrella, K., Chaker, Z., Spoon, J. N., Pastormerlo, L. E., Meincke, F., Sawant, A. C. ... Rodés-Cabau, J. (2023). Persistent and Recurrent Device-Related Thrombus After Left Atrial Appendage Closure: Incidence, Predictors, and Outcomes. JACC: Cardiovascular Interventions, 16(22), 2722-2732. https://doi.org/10.1016/j.jcin.2023.09.017
Betts, T. R., Grygier, M., Nielsen Kudsk, J. E., Schmitz, T., Sandri, M., Casu, G., Bergmann, M., Hildick-Smith, D., Christen, T., Allocco, D. J. & FLXibility investigators (2023). Real-world clinical outcomes with a next-generation left atrial appendage closure device: the FLXibility Post-Approval Study. EP Europace, 25(3), 914-921. https://doi.org/10.1093/europace/euac270
Vij, V., Cruz-González, I., Galea, R., Piayda, K., Nelles, D., Vogt, L., Gloekler, S., Fürholz, M., Meier, B., Räber, L., O'Hara, G., Arzamendi, D., Agudelo, V., Asmarats, L., Freixa, X., Flores-Umanzor, E., De Backer, O., Sondergaard, L., Nombela-Franco, L. ... Sedaghat, A. (2023). Symptomatic vs. non-symptomatic device-related thrombus after LAAC: a sub-analysis from the multicenter EUROC-DRT registry. Clinical Research in Cardiology, 112(12), 1790-1799. https://doi.org/10.1007/s00392-023-02237-w
Eriksson, P., Pihkala, J., Jensen, A. S., Dohlen, G., Liuba, P., Wahlander, H., Sjoberg, G., Hlebowicz, J., Furenas, E., Leirgul, E., Settergren, M., Vithessonthi, K., Nielsen, N.-E., Christersson, C., Sondergaard, L., Sinisalo, J., Nielsen-Kudsk, J. E., Dellborg, M. & Larsen, S. H. (2023). Transcatheter Intervention for Coarctation of the Aorta: A Nordic Population-Based Registry With Long-Term Follow-Up. JACC. Cardiovascular interventions, 16(4), 444-453. https://doi.org/10.1016/j.jcin.2022.11.007
Andersen, A., Matzen, K. L., Andersen, G., Settergren, M., Sjostrand, C., Iversen, H. K., Roine, R. O., Hildick-Smith, D., Spence, J. D., Rhodes, J. F., Kasner, S. E., Sondergaard, L. & Nielsen-Kudsk, J. E. (2022). Atrial fibrillation after closure of patent foramen ovale in the REDUCE clinical study. Catheterization and Cardiovascular Interventions, 99(5), 1551-1557. https://doi.org/10.1002/ccd.30019
Vij, V., Piayda, K., Nelles, D., Gloekler, S., Galea, R., Fürholz, M., Meier, B., Valgimigli, M., O'Hara, G., Arzamendi, D., Agudelo, V., Asmarats, L., Freixa, X., Flores-Umanzor, E., De Backer, O., Sondergaard, L., Nombela-Franco, L., McInerney, A., Korsholm, K. ... Sedaghat, A. (2022). Clinical and echocardiographic risk factors for device-related thrombus after left atrial appendage closure: an analysis from the multicenter EUROC-DRT registry. Clinical Research in Cardiology, 111(11), 1276-1285. https://doi.org/10.1007/s00392-022-02065-4
Lyhne, M. D., Witkin, A. S., Dasegowda, G., Tanayan, C., Kalra, M. K. & Dudzinski, D. M. (2022). Evaluating cardiopulmonary function following acute pulmonary embolism. Expert Review of Cardiovascular Therapy, 20(9), 747-760. https://doi.org/10.1080/14779072.2022.2108789
Korsholm, K., Damgaard, D., Valentin, J. B., Packer, E. J. S., Odenstedt, J., Sinisalo, J., Putaala, J., Næss, H., Al-Jazi, M. A., Karsson, J.-E., Pontoppidan, J., Modrau, B., Hjort, J., Matzen, K. L., Johnsen, S. P. & Nielsen-Kudsk, J. E. (2022). Left atrial appendage occlusion vs novel oral anticoagulation for stroke prevention in atrial fibrillation: Rationale and design of the multicenter randomized occlusion-AF trial. American Heart Journal, 243, 28-38. https://doi.org/10.1016/j.ahj.2021.08.020
Pruszczyk, P., Klok, F. A., Kucher, N., Roik, M., Meneveau, N., Sharp, A. S. P., Nielsen-Kudsk, J. E., Obradović, S., Barco, S., Giannini, F., Stefanini, G., Tarantini, G., Konstantinides, S. & Dudek, D. (2022). Percutaneous treatment options for acute pulmonary embolism: a clinical consensus statement by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function and the European Association of Percutaneous Cardiovascular Interventions. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 18(8), e623-e638. https://doi.org/10.4244/EIJ-D-22-00246
Price, M. J., Ellis, C. R., Nielsen-Kudsk, J. E., Thaler, D., Gupta, N., Koulogiannis, K., Anderson, J. A., Gage, R. & Lakkireddy, D. (2022). Peridevice Leak After Transcatheter Left Atrial Appendage Occlusion: An Analysis of the Amulet IDE Trial. JACC: Cardiovascular Interventions, 15(21), 2127-2138. https://doi.org/10.1016/j.jcin.2022.09.001
Freixa, X., Cepas-Guillén, P., Korsholm, K., Kramer, A., Regueiro, A., Flores-Umanzor, E., Sanchis, L., Arenas-Loriente, A., Jensen, J. M. & Nielsen-Kudsk, J. E. (2022). Usefulness of a novel sizing chart for left atrial appendage occlusion with the Amplatzer Amulet. Catheterization and Cardiovascular Interventions, 100(5), 801-809. https://doi.org/10.1002/ccd.30406
Aplin, M., Andersen, A., Brandes, A., Dominguez, H., Dahl, J. S., Damgaard, D., Iversen, H. K., Iversen, K. K., Nielsen, E., Risum, N., Schmidt, M. R. & Andersen, N. H. (2021). Assessment of patients with a suspected cardioembolic ischemic stroke: A national consensus statement. Scandinavian Cardiovascular Journal, 55(5), 315-325. https://doi.org/10.1080/14017431.2021.1973085
Piayda, K., Hellhammer, K., Nielsen-Kudsk, J. E., Schmidt, B., Mazzone, P., Berti, S., Fischer, S., Lund, J., Montorfano, M., Della Bella, P., Gage, R. & Zeus, T. (2021). Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational Study. BMJ Open, 11(3), Article e040455. https://doi.org/10.1136/bmjopen-2020-040455
Freixa, X., Schmidt, B., Mazzone, P., Berti, S., Fischer, S., Lund, J., Montorfano, M., Della Bella, P., Lam, S. C. C., Cruz-Gonzalez, I., Gage, R., Omran, H., Tarantini, G., Aminian, A. & Nielsen-Kudsk, J. E. (2021). Comparative data on left atrial appendage occlusion efficacy and clinical outcomes by age group in the Amplatzer™ Amulet™ Occluder Observational Study. EP Europace, 23(2), 238–246. https://doi.org/10.1093/europace/euaa262
Arru, C., Ebrahimian, S., Falaschi, Z., Hansen, J. V., Pasche, A., Lyhne, M. D., Zimmermann, M., Durlak, F., Mitschke, M., Carriero, A., Nielsen-Kudsk, J. E., Kalra, M. K. & Saba, L. (2021). Comparison of deep learning, radiomics and subjective assessment of chest CT findings in SARS-CoV-2 pneumonia. Clinical Imaging, 80, 58-66. https://doi.org/10.1016/j.clinimag.2021.06.036
Sedaghat, A., Vij, V., Al-Kassou, B., Gloekler, S., Galea, R., Fürholz, M., Meier, B., Valgimigli, M., O'Hara, G., Arzamendi, D., Agudelo, V., Asmarats, L., Freixa, X., Flores-Umanzor, E., De Backer, O., Søndergaard, L., Nombela-Franco, L., McInerney, A., Korsholm, K. ... Nickenig, G. (2021). Device-Related Thrombus After Left Atrial Appendage Closure: Data on Thrombus Characteristics, Treatment Strategies, and Clinical Outcomes From the EUROC-DRT-Registry. Circulation. Cardiovascular Interventions, 14(5), E010195. Article e010195. https://doi.org/10.1161/CIRCINTERVENTIONS.120.010195
Gade, I. L., Schultz, J. G., Cehofski, L. J., Kjaergaard, B., Severinsen, M. T., Rasmussen, B. S., Vorum, H., Honoré, B. & Kristensen, S. R. (2021). Exhaled breath condensate in acute pulmonary embolism; a porcine study of effect of condensing temperature and feasibility of protein analysis by mass spectrometry. Journal of Breath Research, 15(2), Article 026005. https://doi.org/10.1088/1752-7163/abd3f2
Kasner, S. E., Rhodes, J. F., Andersen, G., Iversen, H. K., Nielsen-Kudsk, J. E., Settergren, M., Sjöstrand, C., Roine, R. O., Hildick-Smith, D., Spence, J. D., Søndergaard, L. & Gore REDUCE Clinical Study Investigators (2021). Five-Year Outcomes of PFO Closure or Antiplatelet Therapy for Cryptogenic Stroke. The New England Journal of Medicine, 384(10), 970-971. https://doi.org/10.1056/NEJMc2033779
De Caterina, A. R., Nielsen-Kudsk, J. E., Schmidt, B., Mazzone, P., Fischer, S., Lund, J., Montorfano, M., Gage, R., Lam, S. C. C. & Berti, S. (2021). Gender difference in left atrial appendage occlusion outcomes: Results from the Amplatzer™ Amulet™ Observational Study. IJC Heart & Vasculature, 35, Article 100848. https://doi.org/10.1016/j.ijcha.2021.100848
Aminian, A., De Backer, O., Nielsen-Kudsk, J. E., Mazzone, P., Berti, S., Fischer, S., Lund, J., Montorfano, M., Lam, S. C. C., Freixa, X., Gage, R., Diener, H.-C. & Schmidt, B. (2021). Incidence and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: insights from the Amplatzer Amulet Observational Post-Market Study. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 17(9), 774-782. https://doi.org/10.4244/EIJ-D-20-01309
Sun, X.-Q., Peters, E. L., Schalij, I., Axelsen, J. B., Andersen, S., Kurakula, K., Gomez-Puerto, M. C., Szulcek, R., Pan, X., da Silva Goncalves Bos, D., Schiepers, R. E., Andersen, A., Goumans, M.-J., Vonk Noordegraaf, A., van der Laarse, W. J., de Man, F. S. & Bogaard, H. J. (2021). Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension. American Journal of Respiratory Cell and Molecular Biology (Online), 64(3), 331-343. https://doi.org/10.1165/rcmb.2020-0105OC
Berti, S., Pastormerlo, L. E., Korsholm, K., Saw, J., Alkhouli, M., Costa, M. P., Odenstedt, J., Packer, E. J., Tondo, C., Santoro, G. & Nielsen-Kudsk, J. E. (2021). Intracardiac echocardiography for guidance of transcatheter left atrial appendage occlusion: An expert consensus document. Catheterization and Cardiovascular Interventions, 98(4), 815-825. https://doi.org/10.1002/ccd.29791
Freixa, X., Tzikas, A., Aminian, A., Flores-Umanzor, E., De Backer, O., Korsholm, K., Ben Yedder, M., Gonzalez-Ferreiro, R., Agudelo-Montañez, V., Gilhofer, T., Simon, F., Samaras, A., Regueiro, A., Sondergaard, L., Cruz-Gonzalez, I., Arzamendi, D., Saw, J., Ibrahim, R. & Nielsen-Kudsk, J. E. (2021). Left atrial appendage occlusion in chicken-wing anatomies: Imaging assessment, procedural, and clinical outcomes of the "sandwich technique". Catheterization and Cardiovascular Interventions, 97(7), E1025-E1032. https://doi.org/10.1002/ccd.29546