Publications

The structural heart disease group at Aarhus University and Aarhus University Hospital has a high level of clinical research activity. Here you can see our recent published papers. 

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List of publications

Garot, P. & Nielsen-Kudsk, J. E. (2026). AnchorMan versus Watchman 2.5: a randomised comparison in left atrial appendage closure. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 22(13), e715-e716. https://doi.org/10.4244/EIJ-D-26-00453
Samaras, A., Karakasis, P., Feidakis, A., Giannakoulas, G., Fragakis, N., Nielsen-Kudsk, J.-E., Freixa, X., Nair, D. G., Freeman, J. V., Bergmann, M., Landmesser, U. & Tzikas, A. (2026). Antithrombotic strategies and DOAC dosing following left atrial appendage occlusion: a network meta-analysis. European Heart Journal - Cardiovascular Pharmacotherapy, 12(1), 38-51. https://doi.org/10.1093/ehjcvp/pvaf078
Lyhne, M. D., Liteplo, A., Muzikansky, A., Kabrhel, C. & Dudzinski, D. M. (2026). Association and Discrimination of TAPSE and S' for Short-Term Outcomes in Acute Pulmonary Embolism. European heart journal. Acute cardiovascular care, 15(9), 706–708. https://doi.org/10.1093/ehjacc/zuag081
Dhar, I. T., Baltsen, C. D., Birrenkott, D. A., Freitas, M. F., Bor, B., Granfeldt, A., Andersen, A., Lyhne, M. D. & Kabrhel, C. (2026). Characteristics and Short-Term Outcomes of Patients With Acute Pulmonary Embolism Requiring Intubation. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 33(5), Article e70317. https://doi.org/10.1111/acem.70317
Yuriditsky, E., Lyhne, M. D., Horowitz, J. M. & Dudzinski, D. M. (2026). Critical Care Management of Acute Pulmonary Embolism. Journal of Intensive Care Medicine, 41(3), 200-213. https://doi.org/10.1177/08850666241311512
Nair, D., Freixa, X., Ellis, C. R., Lakkireddy, D., Nielsen-Kudsk, J. E., Horton, R., Reddy, V. Y., Makkar, A., Ibrahim, R., Agarwal, H., de Backer, O., Sabir, S., Weiler, C., Alkhouli, M. & VERITAS Investigators (2026). Early Outcomes With a Next-Generation Dual-Seal Left Atrial Appendage Occluder: Results From the VERITAS Study. JACC: Clinical Electrophysiology, 12(6), 1331-1341. https://doi.org/10.1016/j.jacep.2026.01.021
Chang, K. E., Birrenkott, D. A., Dam Lyhne, M., Jansson, P. S., Horick, N., Prucnal, C. K., Peters, G. A., Matthews, T. M., Stannek, K., Lee, E. S., Dhar, I. T., Flomenbaum, S. H., Brown, T. M., Freitas, M. F., Wrenn, J. O., Stubblefield, W. B. & Kabrhel, C. (2026). Effect of detection method for right ventricular strain on subsequent interventions for acute pulmonary embolism. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. Advance online publication. https://doi.org/10.1080/24745332.2026.2704729
Cepas-Guillén, P., Albors, C., Mill, J., Aminian, A., Garot, P., De Backer, O., Nielsen-Kudsk, J. E., Iriart, X., Barreiro-Perez, M., Flores-Umanzor, E., Cruz-González, I., Arzamendi, D., Avvedimento, M., Nombela-Franco, L., Leduc, N., Horvilleur, J., Kofoed, K. F., Korsholm, K., Cochet, H. ... Freixa, X. (2026). Impact of device implantation depth on blood flow dynamics after left atrial appendage closure. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 22(8), e444-e454. https://doi.org/10.4244/EIJ-D-25-01328
Nair, D., Lakkireddy, D., Alkhouli, M., Freixa, X., Ellis, C. R., Makkar, A., Shah, D., Weiler, C. & Nielsen-Kudsk, J. E. (2026). Impact of Procedural Experience Implanting a Next Generation Left Atrial Appendage Occluder -VERITAS Study Insights. EP Europace, Article euag289. Advance online publication. https://doi.org/10.1093/europace/euag289
Schmidt, B., Windecker, S., Thaler, D., Ellis, C. R., Nielsen-Kudsk, J. E., Freixa, X., Aminian, A., Anderson, J. A., Gage, R., Alkhouli, M. & Lakkireddy, D. (2026). Incidence, Predictors, Management, and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: The Amulet IDE Randomized Clinical Trial. JAMA Cardiology, 11(5), 469-474. https://doi.org/10.1001/jamacardio.2026.0336
Peichl, P., Tzeis, S., Skowronska, M., Asvestas, D., Baran, J., Casella, M., Casado-Arroyo, R., Jan, M., Kautzner, J., Nielsen-Kudsk, J. E., Kupo, P., Pernat, A., Szegedi, N. & Velagić, V. (2026). Intracardiac echocardiography during invasive electrophysiological procedures. A scientific statement of the European Heart Rhythm Association of the ESC, and the European Association of Percutaneous Cardiovascular Interventions of the ESC. EP Europace, 28(6), Article euag059. https://doi.org/10.1093/europace/euag059
Lee, E. S., Baltsen, C. D., Stubblefield, W. B., Granfeldt, A., Andersen, A., Stannek, K., Dudzinski, D. M., Kabrhel, C. & Lyhne, M. D. (2026). Intubation and Mechanical Ventilation in Patients with Acute Pulmonary Embolism: A Scoping Review. Journal of Intensive Care Medicine, 41(1), 3-11. https://doi.org/10.1177/08850666241285862
Doshi, S. K., Kar, S., Nair, D. G., Waggoner, T., Agarwal, H., Moussavian, M., Kashani, A., Oza, S., Feldman, L., Sadhu, A., DeLurgio, D., Alli, O., Nielsen-Kudsk, J. E., Yamamoto, M., Alkhouli, M., Camm, A. J., Coylewright, M., Gibson, C. M., Granger, C. B. ... CHAMPION-AF Investigators (2026). Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation. The New England Journal of Medicine, 394(21), 2083-2094. https://doi.org/10.1056/NEJMoa2517213
Wunderlich, N. C., Sanchis Ruiz, L., Aminian, A., Berti, S., Räber, L., Galea, R., Freixa, X., Hammerstingl, C., Nielsen-Kudsk, J. E., De Potter, T., Rroku, A., Cruz-Gonzalez, I., De Backer, O. & Garot, P. (2026). Multimodality imaging for pre-, intra-, and postprocedural guidance of left atrial appendage closure: a European Left Atrial Appendage Closure Club (ELAACC) expert consensus statement. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 22(17), e918-e934. https://doi.org/10.4244/EIJ-D-25-01372
Shah, A. P., Freeman, J. V., Alkhouli, M., Agarwal, H., Coylewright, M., Makkar, A., Anderson, J., Gage, R., Freixa, X., Nielsen-Kudsk, J. E. & Lakkireddy, D. (2026). Outcomes for single antiplatelet, dual antiplatelet, or oral anticoagulation after Amulet: Insights from EMERGE LAA post-approval study. Cardiovascular revascularization medicine : including molecular interventions, 86, 1-9. https://doi.org/10.1016/j.carrev.2025.07.012
Velazquez, G., Ruberti, A., Leduc, N., Cepas-Guillen, P., Bajoras, V., Perrin, N., Farjat-Pasos, J., McInerney, A., Lafond, A., Millán, X., Zendjebil, S., O Hara, G., Ibrahim, R., De Backer, O., Cruz-González, I., Arzamendi, D., Sanchis, L., Garot, P., Nielsen-Kudsk, J. E. ... Freixa, X. (2026). Outcomes of left atrial appendage closure in patients with prior mitral valve interventions. Clinical Research in Cardiology. Advance online publication. https://doi.org/10.1007/s00392-026-02979-3
Berti, S., Garot, P., Trimarchi, G., Nielsen-Kudsk, J. E., Lip, G. Y. H., Skurk, C., Caso, V., Boersma, L. V. A., Della Rocca, D. G., Boriani, G. & Camm, A. J. (2026). Percutaneous Left Atrial Appendage Closure: The CHAMPION-like vs CLOSURE-like Patient Phenotype Framework. EP Europace, Article euag286. Advance online publication. https://doi.org/10.1093/europace/euag286
Klok, F. A., Sharp, A., Ahrens, I., Aleksic, M., Ni Ainle, F., Barco, S., Bertoletti, L., Keeling, B., Fengler, K., Helms, J., Jiménez, D., Lang, I. M., Lauw, M. N., Lorusso, R., Martin-Loeches, I., Meijboom, L. J., Meneveau, N., Montero-Cabezas, J., O'sullivan, G. ... Konstantinides, S. V. (2026). Rationale for and approach to establishing a multidisciplinary acute pulmonary embolism expert care team. European Heart Journal: Acute Cardiovascular Care, 15(2), 151-161. https://doi.org/10.1093/ehjacc/zuaf141
Einarsson Askeli, F., Andersen, A., Glise Sandblad, K., Martinell, L., Pivodic, A., Rylander, C., Tavoly, M., Svennerholm, K. & PE-NORDIC Investigators (2026). Reperfusion treatment strategies in acute pulmonary embolism: Study protocol for a multicenter prospective observational study in the Nordic countries (PE-NORDIC). Thrombosis research, 260, Article 109635. https://doi.org/10.1016/j.thromres.2026.109635
Rodenburg, T. C., Higuchi, S., Andersen, S., Stilling, E., Braams, N. J., Kianzad, A., Nossent, E. J., Aman, J., Jensen, M. K., Kim, W. Y., Beijk, M. A. M., Lely, R. J., Winkelman, J. A., Ilkjær, L. B., de Man, F. S., Vonk Noordegraaf, A., Andersen, M. J., Andersen, A., Meijboom, L. J. & Bogaard, H. J. (2026). Right Ventricular Adaptation after Pulmonary Endarterectomy and Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension: A comparative Cardiac MRI-Based Study. European Respiratory Journal, 68(3), Article 2502314. https://doi.org/10.1183/13993003.02314-2025
Slobod, D., Zochios, V., Yusuff, H., Lyhne, M. D. & Denault, A. Y. (2026). Right Ventricular Hemodynamics in Acute Respiratory Distress Syndrome: Monitoring and Implications for Clinical Management. American Journal of Respiratory and Critical Care Medicine, 212(1), 45-58. https://doi.org/10.1164/rccm.202505-1125CI
Garot, P., Mehran, R., de Backer, O., Freeman, J. V., Wunderlich, N., Hibbert, B., Tzikas, A., Nair, D., Berti, S., Saw, J., Freixa, X., Doshi, S. K., Cruz-Gonzalez, I., Coylewright, M., Aminian, A., Price, M. J., Räber, L., Yao, X., Sanchis, L. ... Alkhouli, M. (2026). Standardized endpoint definitions for trials of transcatheter left atrial appendage closure: a consensus from the Left Atrial Appendage Academic Research Consortium. European Heart Journal, Article ehag482. Advance online publication. https://doi.org/10.1093/eurheartj/ehag482
Rosseel, L., Wunderlich, N. C., Berti, S., Aminian, A., Nielsen-Kudsk, J. E., Cruz-Gonzalez, I., Räber, L., Nombela-Franco, L., Shuvy, M., Freixa, X., Garot, P. & De Backer, O. (2026). Transseptal Puncture for Left Atrial Appendage Closure: A Consensus Document From the Second European Left Atrial Appendage Club. Journal of the Society for Cardiovascular Angiography and Interventions, 5(3), Article 104190. https://doi.org/10.1016/j.jscai.2025.104190
Falster, C., Egholm, G., Lambrechtsen, J., Andersen, A., Gaist, T. A., Bauersach, R., Klok, F. A. & Vonk-Noordegraaf, A. (2026). Treatment of acute pulmonary embolism: A comparison of international guideline recommendations. Journal of Thrombosis and Haemostasis, 24(3), 817-836. https://doi.org/10.1016/j.jtha.2025.11.021
Haeusler, K. G., Sposato, L. A., Grygier, M., Potpara, T., Nielsen-Kudsk, J. E., Boersma, L. V. A., Lip, G. Y. H., Schnabel, R. B., Osmancik, P., Schmidt, B., Döhner, W., Kovac, J. & Camm, A. J. (2026). Update on left atrial appendage closure for neurologists. European Stroke Journal, 11(1), Article aakaf018. https://doi.org/10.1093/esj/aakaf018
Lakkireddy, D., Ellis, C. R., Thaler, D., Swarup, V., Gambhir, A., Hermiller, J., Nielsen-Kudsk, J. E., Worthley, S., Nair, D., Schmidt, B., Horton, R., Gupta, N., Anderson, J. A., Zhao, H., Alkhouli, M. & Windecker, S. (2025). 5-Year Results From the AMPLATZER Amulet Left Atrial Appendage Occluder Randomized Controlled Trial. Journal of the American College of Cardiology, 85(11), 1141-1153. https://doi.org/10.1016/j.jacc.2024.10.101
Potpara, T., Markovic, B., Grygier, M., Genovesi, S., Tzikas, A., Boveda, S., Nielsen-Kudsk, J. E., Boriani, G., Lip, G. Y. H. & Camm, A. J. (2025). Adherence to oral thromboprophylaxis in atrial fibrillation: An overview for clinicians. EP Europace, 27(11), Article euaf250. https://doi.org/10.1093/europace/euaf250
Nielsen-Kudsk, J. E., Aminian, A., De Backer, O., Iriart, X., Berti, S., Galea, R., Freixa, X., Räber, L., Cruz-Gonzalez, I., Wunderlich, N. C. & Garot, P. (2025). A new implanter classification system for left atrial appendage closure from the European Left Atrial Appendage Closure Club (ELAACC). EuroIntervention, 21(11), e594-e604. https://doi.org/10.4244/EIJ-D-24-00954
Potpara, T., Grygier, M., Haeusler, K. G., Nielsen-Kudsk, J. E., Berti, S., Genovesi, S., Marijon, E., Boveda, S., Tzikas, A., Boriani, G., Boersma, L. V. A., Tondo, C., Potter, T. D., Lip, G. Y. H., Schnabel, R. B., Bauersachs, R., Senzolo, M., Basile, C., Bianchi, S. ... Camm, A. J. (2025). An International Consensus Practical Guide on Left Atrial Appendage Closure for the Non-implanting Physician: Executive Summary. Thrombosis and Haemostasis, 125(9), 825-846. https://doi.org/10.1055/a-2469-4896
Nielsen-Kudsk, J. E., Schmidt, B., Windecker, S., Shah, N., Gray, W., Ellis, C. R., Koulogiannis, K., Anderson, J. A., Gage, R. & Lakkireddy, D. (2025). Characterization and Clinical Outcomes of High-Risk Device-Related Thrombus in the Amulet IDE Trial. JACC: Clinical Electrophysiology, 11(7), 1543-1554. https://doi.org/10.1016/j.jacep.2025.02.016
Bshennaty, A., Vogl, B. J., Saleh, G., Bavo, A. M., Sularz, A., Ghazal-Aswad, K., Kramer, A. D., Jia, Y., De Beule, M., Nielsen-Kudsk, J. E., De Backer, O., Alkhouli, M. & Hatoum, H. (2025). Comparison of Flow Dynamics After Left Atrial Appendage Occlusion With the Watchman FLX Versus Amulet Devices: Implications for Device-Related Thrombosis. Catheterization and Cardiovascular Interventions, 106(4), 2084-2092. https://doi.org/10.1002/ccd.31710
Garot, P., Nielsen-Kudsk, J.-E., Freixa, X., Berti, S., Wunderlich, N., Cruz-Gonzalez, I., Räber, L., Aminian, A. & De Backer, O. (2025). Contemporary European practice in left atrial appendage closure: results from a survey focusing on planning, techniques and post-implantation management. BMJ Open, 15(2), e090541. Article e090541. https://doi.org/10.1136/bmjopen-2024-090541