Department of Clinical Medicine

Structural Heart

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Publications

The structural heart disease group at Aarhus University and Aarhus University Hospital has a high level of clinical research activity. Here you can see our recent published papers. 

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Axelsen, J. S. (2024). Diastolic adaptation and new treatment strategies in right heart failure. [PhD dissertation, Aarhus University].
Kramer, A. D. (2024). Left Atrial Appendage Closure Diagnosis and Prevention of Device-Related Thrombosis. [PhD dissertation, Aarhus University].
Andersen, S. (2020). Neurohormonal and anti-fibrotic modulation in experimental right ventricular failure. [PhD dissertation, Aarhus University].
Korsholm, K. K. (2020). Novel imaging modalities in transcatheter left atrial appendage occlusion. Procedure and follow-up implications. [PhD dissertation, Aarhus University].
Lyhne, M. D. (2021). Right ventricular function and support in acute pulmonary embolism. [PhD dissertation, Aarhus University].
Lauridsen, H., Andersen, A., Pedersen, M. & Ringgaard, S. (2013). Cardiac function imaging in the axolotl using a new self-gating approach. http://ismrm.org/13/
Østergaard Mariager, C., Søvsø Szocska Hansen, E., Bech, S. K., Munk, A., Lyhne, M. D., Søberg, K., Nielsen, P. F., Ringgaard, S. & Laustsen, C. (2019). Comparison of perfusion markers in the ex-vivo perfused porcine kidney: hyperpolarized [1-13C]pyruvate versus gold standard 1H DCE MRI. Abstract from ESMRMB 2019, Rotterdam, Netherlands.
Johansen, P., Tang, M., Andersen, H. R. & Nielsen-Kudsk, J. E. (2016). Establishing guidelines for valve-in-valve therapy predilatation stent fracturing. Abstract from 26th Annual Meeting SSRCTS, Geilo, Norway.
Engholt, H., Rasmussen, P. D., Tang, M., Nielsen-Kudsk, J. E. & Johansen, P. (2017). Fracturing surgical bioprosthetic heart valves by high-pressure balloon dilatation in-vitro. Abstract from 27th Annual Meeting, Scandinavian Society for Research in Cardiothoracic Surgery, Geilo, Norway.
Nyboe, C., Olsen, M. S., Nielsen-Kudsk, J. E. & Hjortdal, V. E. (2013). Risk of pneumonia in adult patients with atrial septal defect. Abstract from The 5th Joint Scandinavian Conference in Cardiothoracic Surgery, Aarhus, Denmark.
Andersen, A., Povlsen, J. A., Bøtker, H. E. & Nielsen-Kudsk, J. E. (2012). Ischemia and ischemic preconditioning in the hypertrophic and failing right heart. Abstract from PCCS 2013, Cape Town.
Lyhne, M. D., Kabrhel, C., Giordano, N., Andersen, A., Nielsen-Kudsk, J. E., Zheng, H. & Dudzinski, D. (2019). Combination Of Right Ventricular Function And Pulmonary Pressure Improves Prediction Of Adverse Outcome In Acute Pulmonary Embolism. Poster session presented at AHA Scientific Session, Philadelphia, Pennsylvania, United States.
Nielsen-Kudsk, M. H., Ralfs, F. J., Kim, W. Y., Ringgaard, S., Nielsen-Kudsk, J. E. & Johansen, P. (2018). Compromised sinus of valsalva flow and transcatheter aortic valve thrombosis. Poster session presented at 28th Annual Meeting, Scandinavian Society for Research in Cardiothoracic Surgery, Geilo, Norway.
Udholm, S., Nyboe, C., Nielsen-Kudsk, J. E. & Hjortdal, V. E. (2017). Health profile in adults with small atrial septal defects. Poster session presented at 7th World Congress of Pediatric Cardiology & Cardiac Surgery, Barcelona, Spain.
Salmon, M. K., Hammer, K. E., Johansen, P. & Nielsen-Kudsk, J. E. (2019). Left Atrial Appendage Occlusion: To Tug or Not To Tug?. Poster session presented at EuroPCR in Interventional Cardiovascular Medicine, Paris, France.
Udholm, S., Nyboe, C., Karunanithi, Z., Christensen, A. L., Redington, A., Nielsen-Kudsk, J. E. & Hjortdal, V. E. (2019). Lifelong burden of small unrepaired atrial septal defect: Results from the Danish National Patient Registry. Poster session presented at 22nd Annual Update on Pediatric and Congenital Cardiovascular Disease, California, United States.
Nybo, R. F., Nielsen-Kudsk, J. E. & Johansen, P. (2017). Mapping of catheter tug forces during left atrial appendage occlusion. Poster session presented at 27th Annual Meeting, Scandinavian Society for Research in Cardiothoracic Surgery, Geilo, Norway.
Agger, P., Ilkjær, C., Laustsen, C., Smerup, M. H., Nielsen-Kudsk, J. E., Pedersen, M. & Hjortdal, V. E. (2014). Myocardial remodelling due to right ventricular dilatation in congenital heart disease. Poster session presented at PhD Day 2014, Aarhus, Denmark.
Udholm, S., Nyboe, C., Nielsen-Kudsk, J. E. & Hjortdal, V. E. (2016). Small unclosed atrial septal defects in adult patients. Poster session presented at The 8th Joint Scandinavian Conference in Cardiothoracic Surgery, Reykjavik, Iceland.
Rasmussen, P. D., Engholt, H., Benhassen, L. L., Tang, M., Andersen, H. R., Nielsen-Kudsk, J. E. & Johansen, P. (2017). The effects of the aortic root on the fracturing pressure of bioprosthetic heart valves. Poster session presented at 27th Annual Meeting, Scandinavian Society for Research in Cardiothoracic Surgery, Geilo, Norway.
Ralfs, F. J., Nielsen-Kudsk, M. H., Nielsen-Kudsk, J. E. & Johansen, P. (2018). The functional effect of left atrial appendage occlusion. Poster session presented at 28th Annual Meeting, Scandinavian Society for Research in Cardiothoracic Surgery, Geilo, Norway.
Andersen, A., Nielsen, J. M., Schou, U. K., Peters, C. D., Sloth, E. & Nielsen-Kudsk, J. E. (2007). Effects of PDE5-inhibition by sildenafil in the pressure overloaded right heart. Poster session presented at ESC Congress 2007, Wien, Austria.
Christensen, S. D., Sivesgaard, K., Nielsen-Kudsk, J. E., Hasenkam, J. M. & Sloth, E. (2008). Effects of Sildenafil on Left Ventricular Hypertrophy - A study on piglets operated by aortic banding. Poster session presented at DASAIM's årsmøde, København, Denmark.
Christensen, S. D., Sivesgaard, K., Baandrup, U. T., Nielsen-Kudsk, J. E., Sloth, E. & Hasenkam, J. M. (2008). Erosion of a banding through the aortic wall. Poster session presented at 18th Annual Meeting of the Scandinavian Society for Research in Cardiothoracic Surgery, Geilo, Norway.
Andersen, A., Povlsen, J. A., Bøtker, H. E. & Nielsen-Kudsk, J. E. (2012). Right ventricular hypertrophy and failure abolish cardioprotection by ischemic preconditioning. Poster session presented at ESC Congress 2012, Munchen, Germany.
Andersen, A., Nielsen, J. M., Holmboe, S., Vildbrad, M. D. & Nielsen-Kudsk, J. E. (2012). The guanylate cyclase stimulator BAY 41-2272 does not prevent right ventricular hypertrophy and failure alone or in combination with sildenafil.
Østergaard Mariager, C., Søvsø Szocska Hansen, E., Bech, S. K., Munk, A., Lyhne, M. D., Søberg, K., Nielsen, P. F., Ringgaard, S. & Laustsen, C. (2019). Ex-vivo investigation of renal metabolic heterogeneity using hyperpolarized [1-13C]pyruvate MRI: a novel renal perfusion device. In ISMRM 2019 https://www.ismrm.org/members-only/past-annual-scientific-meeting-proceedings-and-syllabi/#gsc.tab=0
Ilkjær, L., Nielsen-Kudsk, J. E. & Allermand, H. (2009). Lungeemboli. In Thoraxkirurgi (2 ed., pp. 221-228). FADL's Forlag.
Nielsen-Kudsk, J. E., Andersen, A., Korsholm, K. & Grove, E. L. (2023). Antithrombotic therapy in patients with patent foramen ovale (PFO), PFO closure, left ventricular mural thrombus, atrial thrombus, and catheter-related thrombosis. In Antithrombotic therapy in patients with patent foramen ovale (PFO), PFO closure, left ventricular mural thrombus, atiral thrombus, and catheter-related thrombosis (pp. 221-230). Oxford University Press.
Andersen, A. (2008). Effects of phosphodiesterase-5 inhibition by sildenafil in the pressure overloaded right heart: Viagras effekt på højresidig hjertevægsfortykkelse. Det Sundhedsvidenskabelige Fakultet Aarhus.
Christensen, L. J., Andersen, A., Hørsdal, O. K., Homilius, C., Seefeldt, J. M., Dragsbæk, S. J., Ellegaard, M. S., Larsen, A. M., Kramer, A. D., Overgaard, A., Hansen, J. V., Berg-Hansen, K., Gopalasingam, N., Nielsen, B. R. R. & Lyhne, M. D. (2025). Hemodynamic effects of the ketone body 3-hydroxybutyrate in a porcine acute pulmonary embolism model. European Heart Journal: Acute Cardiovascular Care, 14(Supplement 1). https://doi.org/10.1093/ehjacc/zuaf044.206
Udholm, S., Nyboe, C., Karunanithi, Z., Christensen, A. I., Redington, A., Nielsen-Kudsk, J. E. & Hjortdal, V. E. (2019). Lifelong burden of small unrepaired atrial septal defect: Results from the Danish National Patient Registry. World Journal for Pediatric and Congenital Heart Surgery, 10(2). https://doi.org/10.1177/2150135119830271
Dragsbaek, S. J., Lyhne, M. D., Hansen, J. V., Pedersen, C. C. E., Jujo-Sanada, T., Karout, L., Kalra, M. K., Nielsen-Kudsk, J. E. & Andersen, A. (2023). A porcine model of human-like chronic thromboembolic pulmonary disease. Thrombosis Research Supplement, 231, 25-28. https://doi.org/10.1016/j.thromres.2023.09.011
Korsholm, K., Kramer, A., Andersen, A., Saw, J., Nørgaard, B. L., Jensen, J. M. & Nielsen-Kudsk, J. E. (2023). Correction to: Left atrial appendage sealing performance of the Amplatzer Amulet and Watchman FLX device. Journal of Interventional Cardiac Electrophysiology, 66(2), Article 403. https://doi.org/10.1007/s10840-022-01397-5
Salmon, M. K., Hammer, K. E., Nygaard, J. V., Korsholm, K., Johansen, P. & Nielsen-Kudsk, J. E. (2020). Correction to: Left atrial appendage occlusion with the Amulet device: to tug or not to tug? Journal of Interventional Cardiac Electrophysiology. https://doi.org/10.1007/s10840-020-00839-2
Andersen, A. & Andersen, M. J. (2021). Editorial commentary: Elevated left atrial pressure in heart failure: should you relieve the pressure? Trends in Cardiovascular Medicine, 31(7), 433-434. https://doi.org/10.1016/j.tcm.2020.10.008
Kasner, S. E., Rhodes, J. F., Andersen, G., Iversen, H. K., Nielsen-Kudsk, J. E., Settergren, M., Sjöstrand, C., Roine, R. O., Hildick-Smith, D., Spence, J. D., Søndergaard, L. & Gore REDUCE Clinical Study Investigators (2021). Five-Year Outcomes of PFO Closure or Antiplatelet Therapy for Cryptogenic Stroke. The New England Journal of Medicine, 384(10), 970-971. https://doi.org/10.1056/NEJMc2033779
Nielsen-Kudsk, J. E. (2022). Left Atrial Appendage Occlusion: Sex Matters, But Not in the Long Run. JACC: Cardiovascular Interventions, 15(21), 2156-2157. https://doi.org/10.1016/j.jcin.2022.07.043
Nielsen-Kudsk, J. E. (2021). Prevention of Left Atrial Appendage Device-Related Thrombosis: Is Reduced-Dose Direct Oral Anticoagulation the Way Forward? JACC: Cardiovascular Interventions, 14(21), 2365-2367. https://doi.org/10.1016/j.jcin.2021.08.004
Nielsen-Kudsk, J. E. & Berti, S. (2019). Reply: Intracardiac Echocardiography From the Left Atrium to Guide Left Atrial Appendage Occlusion. JACC. Cardiovascular interventions, 12(19), 1984-1985. https://doi.org/10.1016/j.jcin.2019.07.039
Korsholm, K., Jensen, J. M., Nørgaard, B. L., Saw, J. & Nielsen-Kudsk, J. E. (2021). Reply: Alternative Hypothesis for the Discrepancy in Peridevice Leak Detection. JACC. Cardiovascular interventions, 14(8), 925-926. https://doi.org/10.1016/j.jcin.2021.02.043
Nielsen-Kudsk, J. E. & ICE LAA Study Investigators and Authors (2023). Reply: Is Intracardiac Echocardiography-Guided Left Atrial Appendage Closure the Icing on the Cake? JACC. Cardiovascular interventions, 16(11), 1421. https://doi.org/10.1016/j.jcin.2023.05.009
Bonnesen, K., Andersen, A., Simonsen, C. Z., Nielsen-Kudsk, J. E. & Schmidt, M. (2025). Reply: Recurrent Ischemic Stroke After PFO Closure: Unconsidered Low RoPE Score and Thrombophilia. Journal of the American College of Cardiology, 85(4), e65-e65. https://doi.org/10.1016/j.jacc.2024.11.036
Dragsbaek, S. J., Kirk, M. E. & Andersen, A. (2025). Reply to the letter to the editor on: Cardiopulmonary remodeling following repetitive acute pulmonary emboli and inhibition of endogenous fibrinolysis in a porcine model. International Journal of Cardiology, 440, Article 133690. https://doi.org/10.1016/j.ijcard.2025.133690
Andersen, S., Bjerre, J. V., Bækgaard, K., Idorn, L. & Andersen, M. J. (2025). Severe Precapillary Pulmonary Hypertension and Right Ventricular Failure After Hematopoietic Stem Cell Transplantation: Successful Outcomes With Aggressive Upfront Triple Therapy. Pediatric Blood and Cancer, 72(5), Article e31623. https://doi.org/10.1002/pbc.31623
Schultz, J., Andersen, A., Lyhne, M. D., Arcanjo, D. D. R., Kjaergaard, B., Simonsen, U. & Nielsen-Kudsk, J. E. (2020). The authors reply. Critical Care Medicine, 48(10), e982-e983. https://doi.org/10.1097/CCM.0000000000004517
Garot, P. & Nielsen-Kudsk, J. E. (2026). AnchorMan versus Watchman 2.5: a randomised comparison in left atrial appendage closure. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 22(13), e715-e716. https://doi.org/10.4244/EIJ-D-26-00453
Nielsen-Kudsk, J. E. (2025). A Novel Left Atrial Appendage Occlusion System: Is It in Zenith? JACC. Cardiovascular interventions, 18(24), 3084-3086. https://doi.org/10.1016/j.jcin.2025.10.044
Nielsen-Kudsk, J. E., Andersen, S. & Andersen, A. (2018). Can computer assisted analysis of a standard 12‑lead ECG be used for early diagnosis and monitoring of disease progression in pulmonary hypertension? International Journal of Cardiology, 273, 221-222. https://doi.org/10.1016/j.ijcard.2018.08.057
Andersen, A., van der Feen, D. E., Andersen, S., Schultz, J. G., Hansmann, G. & Bogaard, H. J. (2020). Animal models of right heart failure. Cardiovascular Diagnosis and Therapy, 10(5), 1561-1579. https://doi.org/10.21037/cdt-20-400

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Revised 11.09.2025
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Kristina Laut Matzen