Department of Clinical Medicine

Structural Heart

 Department of Clinical Medicine structuralheart Publications

Publications

The structural heart disease group at Aarhus University and Aarhus University Hospital has a high level of clinical research activity. Here you can see our recent published papers. 

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List of publications

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Holmboe, S., Andersen, A., Vildbrad, M. D., Nielsen, J. M., Ringgaard, S. & Nielsen-Kudsk, J. E. (2013). Iloprost improves ventricular function in the hypertrophic and functionally impaired right heart by direct stimulation. Pulmonary Circulation, 3(4), 870-9. https://doi.org/10.1086/674760
Groth, K. A., Erik Nielsen-Kudsk, J., Nørgaard, B. L. & Andersen, N. H. (2013). Internal mammary arteriovenous fistula found late after aortic root replacement. European Heart Journal Cardiovascular Imaging, 14(8), 831. https://doi.org/10.1093/ehjci/jet025
Nyboe, C., Nielsen-Kudsk, J. E. & Hjortdal, V. (2013). Is closure of atrial septal defects in adults still controversial? European Journal of Cardio-Thoracic Surgery, 45(1), 202. https://doi.org/10.1093/ejcts/ezt298
Andersen, A. & Nielsen-Kudsk, J. E. (2013). Is the effect of cGMP modulation by phosphodiesterase-5 inhibition dependent on the magnitude of pressure overload in the hypertrophic right heart? Experimental Physiology, 98(12), 1718. https://doi.org/10.1113/expphysiol.2013.075697
Laut, K. G., Gale, C. P., Pedersen, A. B., Fox, K. A. A., Lash, T. L. & Kristensen, S. D. (2013). Persistent geographical disparities in the use of primary percutaneous coronary intervention in 120 European regions: exploring the variation. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 9(4), 469-76. https://doi.org/10.4244/EIJV9I4A76
Andersen, C. U., Sønderskov, L. D., Nielsen-Kudsk, J. E., Simonsen, U., Bendstrup, E., Hilberg, O. & Mellemkjær, S. (2013). [Pulmonary hypertension--classification, work-up and treatment]. Ugeskrift for Læger, 175(23), 1642-1645.
Andersen, C. U., Mellemkjær, S., Nielsen-Kudsk, J. E., Bendstrup, E., Hilberg, O. & Simonsen, U. (2013). Pulmonary hypertension in chronic obstructive and interstitial lung diseases. International Journal of Cardiology, 168(3), 1795-1804. https://doi.org/10.1016/j.ijcard.2013.06.033
Andersen, A., Povlsen, J. A., Bøtker, H. E. & Nielsen-Kudsk, J. E. (2013). Right ventricular hypertrophy and failure abolish cardioprotection by ischaemic pre-conditioning. European Journal of Heart Failure. https://doi.org/10.1093/eurjhf/hft105
Nyboe, C., Olsen, M. S., Nielsen-Kudsk, J. E. & Hjortdal, V. E. (2013). Risk of pneumonia in adult patients with atrial septal defect. Abstract from The 5th Joint Scandinavian Conference in Cardiothoracic Surgery, Aarhus, Denmark.
Andersen, A., Nielsen, J. M., Holmboe, S., Vildbrad, M. D. & Nielsen-Kudsk, J. E. (2013). The Effects of Cyclic Guanylate Cyclase Stimulation on Right Ventricular Hypertrophy and Failure Alone and in Combination with Phosphodiesterase-5 Inhibition. Journal of Cardiovascular Pharmacology and Therapeutics. https://doi.org/10.1097/FJC.0b013e318294a1cf
Andersen, C. U., Mellemkjær, S., Nielsen-Kudsk, J. E., Bendstrup, E., Simonsen, U. & Hilberg, O. (2012). Diagnostic and prognostic role of biomarkers for pulmonary hypertension in interstitial lung disease. Respiratory Medicine. https://doi.org/10.1016/j.rmed.2012.09.003
Andersen, C. U., Mellemkjær, S., Nielsen-Kudsk, J. E., Sønderskov, L. D., Laursen, B. E., Simonsen, U. & Hilberg, O. (2012). Echocardiographic screening for pulmonary hypertension in stable COPD out-patients and NT-proBNP as a rule-out test. C O P D, 505. https://doi.org/10.3109/15412555.2012.695818
Kristensen, S. D., Fajadet, J., Di Mario, C., Kaifoszova, Z., Laut, K. G., Deleanu, D., Gilard, M., Guagliumi, G., Goktekin, O., Jorgova, J., Kanakakis, J., Ostojic, M., Pereira, H., Sabate, M., Sobhy, M., Vrints, C., Wijns, W. & Widimsky, P. (2012). Implementation of primary angioplasty in Europe: stent for life initiative progress report. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 8(1), 35-42. https://doi.org/10.4244/EIJV8I1A7
Andersen, A., Povlsen, J. A., Bøtker, H. E. & Nielsen-Kudsk, J. E. (2012). Ischemia and ischemic preconditioning in the hypertrophic and failing right heart. Abstract from PCCS 2013, Cape Town.
Andersen, A., Povlsen, J. A., Bøtker, H. E. & Nielsen-Kudsk, J. E. (2012). Ischemic Preconditioning Reduces Right Ventricular Infarct Size through Opening of Mitochondrial Potassium Channels. Cardiology, 123(3), 177-80. https://doi.org/10.1159/000342481
Andersen, K. H., Iversen, M. J., Kjaergaard, J., Mortensen, J., Nielsen-Kudsk, J. E., Bendstrup, E., Videbaek, R. & Carlsen, J. (2012). Prevalence, predictors, and survival in pulmonary hypertension related to end-stage chronic obstructive pulmonary disease. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 31(4), 373–380. https://doi.org/10.1016/j.healun.2011.11.020
Andersen, C. U., Mellemkjær, S., Hilberg, O., Nielsen-Kudsk, J. E., Simonsen, U. & Bendstrup, E. (2012). Pulmonary hypertension in interstitial lung disease: Prevalence, prognosis and 6 min walk test. Respiratory Medicine, 106(6), 875–882. https://doi.org/10.1016/j.rmed.2012.02.015
Andersen, A., Povlsen, J. A., Bøtker, H. E. & Nielsen-Kudsk, J. E. (2012). Right ventricular hypertrophy and failure abolish cardioprotection by ischemic preconditioning. Poster session presented at ESC Congress 2012, Munchen, Germany.
Laut, K. G. & Foldspang, A. (2012). The effects on length of stay of introducing a fast track patient pathway for myocardial infarction: a before and after evaluation. Health Services Management Research, 25(1), 31-4. https://doi.org/10.1258/hsmr.2011.011021
Andersen, A., Nielsen, J. M., Holmboe, S., Vildbrad, M. D. & Nielsen-Kudsk, J. E. (2012). The guanylate cyclase stimulator BAY 41-2272 does not prevent right ventricular hypertrophy and failure alone or in combination with sildenafil.
Andersen, C. U., Hilberg, O., Mellemkjær, S., Nielsen-Kudsk, J. E. & Simonsen, U. (2011). Apelin and pulmonary hypertension. Pulmonary Circulation, 1(3), 334-46. https://doi.org/10.4103/2045-8932.87299
Laut, K. G., Pedersen, A. B., Lash, T. & Kristensen, S. D. (2011). Barriers to Implementation of Primary Percutaneous Coronary Intervention in Europe. European Cardiology, 7(2), 108-112. http://www.touchcardiology.com/journals/editions/european-cardiology-volume-7-issue-2
Kristiansen, S. B., Løfgren, B., Nielsen, J. M., Støttrup, N. B., Buhl, E. S., Nielsen-Kudsk, J. E., Nielsen, T. T., Rungby, J., Flyvbjerg, A. & Nielsen, T. T. (2011). Comparison of two sulfonylureas with high and low myocardial K(ATP) channel affinity on myocardial infarct size and metabolism in a rat model of type 2 diabetes. Diabetologia, 54(2), 451-8. https://doi.org/10.1007/s00125-010-1970-y
Nielsen-Kudsk, J. E., Jóanesarson, J. & Bøttcher, M. (2011). Pulmonary hypertension due to a large acquired systemic arteriovenous fistula. Heart. https://doi.org/10.1136/heartjnl-2011-300926
Laut, K. G., Kaifoszova, Z. & Kristensen, S. D. (2011). Status of Stent for Life Initiative across Europe. Journal of Cardiovascular Medicine (Hagerstown), 12(12), 856-9. https://doi.org/10.2459/JCM.0b013e32834da583
Halbirk, M., Nørrelund, H., Møller, N., Holst, J. J., Schmitz, O., Nielsen, B. R. R., Nielsen-Kudsk, J. E., Nielsen, S. S., Nielsen, T. T., Eiskjær, H., Bøtker, H. E. & Wiggers, H. (2010). Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure. American Journal of Physiology: Heart and Circulatory Physiology, 298(3), 1096-1102.
Halbirk, M., Nørrelund, H., Møller, N., Holst, J. J., Schmitz, O., Nielsen, R., Nielsen-Kudsk, J. E., Nielsen, S. S., Toftegård, T., Eiskjær, H., Bøtker, H. E. & Wiggers, H. (2010). Cardiovascular and Metabolic Effects of 48-Hour Glucagon-like Peptide 1 Infusion in Compensated Chronic Heart Failure Patients. American Journal of Physiology: Heart and Circulatory Physiology, 298(3), H1096-102. https://doi.org/10.1152/ajpheart.00930.2009
Halbirk, M., Nørrelund, H., Møller, N., Schmitz, O., Gøtzsche, L., Nielsen, B. R. R., Nielsen-Kudsk, J. E., Nielsen, S. S., Nielsen, T. T., Eiskjær, H., Bøtker, H. E. & Wiggers, H. (2010). Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function. American Journal of Physiology: Heart and Circulatory Physiology, 299(4), 1220-25.
Halbirk, M., Nørrelund, H., Møller, N., Schmitz, O., Gøtzsche, L., Nielsen, R., Nielsen-Kudsk, J. E., Nielsen, S. S., Nielsen, T. T., Eiskjær, H., Bøtker, H. E. & Wiggers, H. (2010). Suppression of Circulating Free Fatty Acids with Acipimox in Chronic Heart Failure Patients Changes Whole Body Metabolism but Does not Affect Cardiac Function. American Journal of Physiology: Heart and Circulatory Physiology, 299(4), H1220-5. https://doi.org/10.1152/ajpheart.00475.2010
Kristiansen, S. B., Solskov, L., Jessen, N., Løfgren, B., Schmitz, O., Nielsen-Kudsk, J. E., Nielsen, T. T., Bøtker, H. E. & Lund, S. (2009). 5-Aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside Increases Myocardial Glucose Uptake during Reperfusion and Induces Late Pre-conditioning: Potential Role of AMP-Activated Protein Kinase. Basic & Clinical Pharmacology & Toxicology, 105(1), 10-16. https://doi.org/10.1111/j.1742-7843.2009.00402.x
Rasmussen, T. B., Dalager, S., Andersen, N. H., Hansen, T. K. & Nielsen-Kudsk, J. E. (2009). Fatal giant cell myocarditis in a patient with multiple autoimmune disorders. BMJ Case Reports, 2009. https://doi.org/10.1136/bcr.09.2008.0997
Galiè, N., Hoeper, M. M., Humbert, M., Torbicki, A., Vachiery, J.-L., Barbera, J. A., Beghetti, M., Corris, P., Gaine, S., Gibbs, J. S., Gomez-Sanchez, M. A., Jondeau, G., Klepetko, W., Opitz, C., Peacock, A., Rubin, L., Zellweger, M., Simonneau, G., ESC Committee for Practice Guidelines (CPG) ... Authors/Task Force Members (2009). Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). European Heart Journal. https://doi.org/10.1093/eurheartj/ehp297
Ilkjær, L., Nielsen-Kudsk, J. E. & Allermand, H. (2009). Lungeemboli. In Thoraxkirurgi (2 ed., pp. 221-228). FADL's Forlag.
Kristiansen, S. B., Løfgren, B., Støttrup, N., Kimose, H.-H., Nielsen-Kudsk, J. E., Bøtker, H. E. & Nielsen, T. T. (2008). CARDIOPROTECTION BY l-GLUTAMATE DURING POSTISCHAEMIC REPERFUSION: REDUCED INFARCT SIZE AND ENHANCED GLYCOGEN RESYNTHESIS IN A RAT INSULIN-FREE HEART MODEL. Clinical and Experimental Pharmacology and Physiology. https://doi.org/10.1111/j.1440-1681.2008.04914.x
Andersen, A., Nielsen, J. M., Peters, C. D., Schou, U. K., Sloth, E. & Nielsen-Kudsk, J. E. (2008). Effects of phosphodiesterase-5 inhibition by sildenafil in the pressure overloaded right heart. European Journal of Heart Failure, 10(12), 1158-1165. https://doi.org/10.1016/j.ejheart.2008.09.016
Andersen, A. (2008). Effects of phosphodiesterase-5 inhibition by sildenafil in the pressure overloaded right heart: Viagras effekt på højresidig hjertevægsfortykkelse. Det Sundhedsvidenskabelige Fakultet Aarhus.
Christensen, S. D., Sivesgaard, K., Nielsen-Kudsk, J. E., Hasenkam, J. M. & Sloth, E. (2008). Effects of Sildenafil on Left Ventricular Hypertrophy - A study on piglets operated by aortic banding. Poster session presented at DASAIM's årsmøde, København, Denmark.
Christensen, S. D., Sivesgaard, K., Baandrup, U. T., Nielsen-Kudsk, J. E., Sloth, E. & Hasenkam, J. M. (2008). Erosion of a banding through the aortic wall. Poster session presented at 18th Annual Meeting of the Scandinavian Society for Research in Cardiothoracic Surgery, Geilo, Norway.
Eiskjaer, H., Nielsen-Kudsk, J. E., Mølgård, H., Severinsen, I. K. & Ilkjaer, L. (2008). Medicin eller mekanik til patienter på ventelisten til hjertetransplantation? Ugeskrift for Læger, 170(1), 63; author reply 64.
Terkelsen, A. J., Nielsen-Kudsk, J. E., Andersen, H. R. & Lassen, J. F. (2008). Telemedicinsk praehospital diagnostik og visitation af en patient med akut lungeemboli. Ugeskrift for Læger, 170(9), 753.
Poulsen, S. H., Praestholm, M., Munk, K., Wierup, P., Egeblad, H. & Nielsen-Kudsk, J. E. (2008). Ventricular septal rupture complicating acute myocardial infarction: clinical characteristics and contemporary outcome. Annals of Thoracic Surgery, 85(5), 1591-6. https://doi.org/10.1016/j.athoracsur.2008.01.010
Andersen, A., Nielsen, J. M., Schou, U. K., Peters, C. D., Sloth, E. & Nielsen-Kudsk, J. E. (2007). Effects of PDE5-inhibition by sildenafil in the pressure overloaded right heart. Poster session presented at ESC Congress 2007, Wien, Austria.
Poulsen, S. H., Søgaard, P., Nielsen-Kudsk, J. E. & Egeblad, H. (2007). Recovery of left ventricular systolic longitudinal strain after valve replacement in aortic stenosis and relation to natriuretic peptides. Journal of the American Society of Echocardiography, 20(7), 877-84.
Mortensen, U., Nørgaard, B. L., Nielsen-Kudsk, J. E., Kristensen, J., Mæng, M. & Nielsen, T. T. (2006). A phase of increased ST elevation during coronary occlusion following ischemic preconditioning. Basic Research in Cardiology, 101(2), 140-8.
Mortensen, U., Nielsen-Kudsk, J. E., Søndergaard, H., Jakobsen, P., Jensen, BS., Schmitz, O. & Nielsen, T. T. (2006). Effect of the oral hypoglycaemic sulfonylurea glibenclamide, a blocker of ATP-sensitive potassium channels, on walking distance in patients with intermittent claudication. Diabet. Med., 23(3), 327-30.
Busk, M., Mæng, M., Kristensen, J., Berg, J. S., Mortensen, U., Nielsen, T. T. & Nielsen-Kudsk, J. E. (2006). Effects of levosimendan on myocardial infarct size and hemodynamics in a closed-chest porcine ischemia-reperfusion model. Cardiovasc Drugs Ther., 20(5), 335-42.
Mellemkjær, S., Ilkjær, L. B., Klaaborg, K. E., Christiansen, C. L., Severinsen, I. K., Nielsen-Kudsk, J. E., Allermand, H., Egeblad, H. & Kristensen, B. Ø. (2006). Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. Ten years experience in Denmark. Scandinavian Cardiovascular Journal, 40(1), 49-53.
Kristiansen, S. B., Nielsen-Kudsk, J. E., Bøtker, H. E. & Nielsen, T. T. (2005). Effects of KATP channes modulation on myocardial glycogen content, lactate, and amino acids in non-ischemic and ischemic rat hearts. J Cardiovasc Pharmacol., 45(5), 456-61.
Wiggers, H., Nørrelund, H., Nielsen, S. S., Andersen, N. H., Nielsen-Kudsk, J. E., Christiansen, J. S., Nielsen, T. T., Møller, N. & Bøtker, H. E. (2005). Influence of insulin and free fatty acids on contractile function in patients with chronically stunned and hibernating myocardium. Am. J. Physiol. Heart Circ Physiol, 289(2), H938-46.
Kristiansen, S. B., Henning, O., Kharbanda, R. K., Nielsen-Kudsk, J. E., Schmidt, M. R., Reddington, A. N., Nielsen, T. T. & Bøtker, H. E. (2005). Remote preconditioning reduces ischemic injury in the explanted heart by a KATP channel-dependent mechanism. Am. J. Physiol. Heart Circ Physiol, 288(3), H1252-6.

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Revised 11.09.2025
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Kristina Laut Matzen