Publications

The structural heart disease group at Aarhus University and Aarhus University Hospital has a high level of clinical research activity. Here you can see our recent published papers.

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List of publications

Merit, V. T., Kirk, M. E., Schultz, J. G., Hansen, J. V., Lyhne, M. D., Kramer, A. D., Pedersen, C. C. E., Karout, L., Kalra, M. K., Andersen, A. & Nielsen-Kudsk, J. E. (2024). Changes in Pulmonary Vascular Resistance and Obstruction Score Following Acute Pulmonary Embolism in Pigs. Critical care explorations, 6(2), E1040. https://doi.org/10.1097/CCE.0000000000001040

Andersen, S., Laursen, P. H., Wood, G. J., Lyhne, M. D., Madsen, T. L., Hansen, E. S. S., Johansen, P., Kim, W. Y. & Andersen, M. J. (2024). Comparison of admittance and cardiac magnetic resonance generated pressure-volume loops in a porcine model. Physiological Measurement, 45(5), Article 055014. https://doi.org/10.1088/1361-6579/ad4a03

Nirmalan, J. G., Kramer, A., Korsholm, K., Jensen, J. M. & Nielsen-Kudsk, J. E. (2024). Computed tomography-based device-sizing in Amplatzer Amulet left atrial appendage occlusion. Journal of Interventional Cardiac Electrophysiology, 67(4), 785-795. https://doi.org/10.1007/s10840-023-01665-y

Axelsen, J. S. (2024). Diastolic adaptation and new treatment strategies in right heart failure. [PhD dissertation, Aarhus University].

Andersen, S., Axelsen, J. S., Nielsen-Kudsk, A. H., Schwab, J., Jensen, C. D., Ringgaard, S., Andersen, A., Smal, R., Llucià-Valldeperas, A., Handoko de Man, F., Igreja, B. & Pires, N. (2024). Effects of dopamine β-hydroxylase inhibition in pressure overload-induced right ventricular failure. Pulmonary Circulation, 14(4), e70008. Article e70008. https://doi.org/10.1002/pul2.70008

Eppinger, S., Piayda, K., Galea, R., Sandri, M., Maarse, M., Güner, A., Karabay, C. Y., Pershad, A., Ding, W. Y., Aminian, A., Akin, I., Davtyan, K. V., Chugunov, I. A., Marijon, E., Rosseel, L., Schmidt, T. R., Amabile, N., Korsholm, K., Lund, J. ... Nielsen-Kudsk, J. E. (2024). Embolization of percutaneous left atrial appendage closure devices: timing, management and clinical outcomes. Cardiovascular revascularization medicine : including molecular interventions, 64, 7-14. https://doi.org/10.1016/j.carrev.2024.02.014

Nielsen-Kudsk, J. E., Kramer, A., Andersen, A., Kim, W. Y. & Korsholm, K. (2024). First-in-human left atrial appendage closure using the WATCHMAN FLX Pro device: a case report. European Heart Journal - Case Reports, 8(4), Article ytae135. https://doi.org/10.1093/ehjcr/ytae135

Vogl, B. J., Vitale, E., Ahn, S., Sularz, A., Chavez Ponce, A., Lo Russo, G. V., Collins, J., Bavo, A. M., El Shaer, A., Kramer, A., Jia, Y., Lulic, D., De Beule, M., Nielsen-Kudsk, J. E., De Backer, O., Alkhouli, M. & Hatoum, H. (2024). Flow Dynamic Factors Correlated With Device-Related Thrombosis After Left Atrial Appendage Occlusion. JACC: Advances, 3(11), Article 101339. https://doi.org/10.1016/j.jacadv.2024.101339

Lyhne, M. D., Schultz, J. G., Mortensen, C. S., Kramer, A., Nielsen-Kudsk, J. E. & Andersen, A. (2024). Immediate cardiopulmonary responses to consecutive pulmonary embolism: a randomized, controlled, experimental study. BMC Pulmonary Medicine, 24(1), Article 233. https://doi.org/10.1186/s12890-024-03006-9

Saw, J., Vij, V., Galea, R., Piayda, K., Nelles, D., Vogt, L., Gloekler, S., Fürholz, M., Meier, B., Räber, L., O'Hara, G., Arzamendi, D., Agudelo, V., Asmarats, L., Freixa, X., Flores-Umanzor, E., De Backer, O., Sondergaard, L., Nombela-Franco, L. ... Afzal, S. (2024). Impact of gender in patients with device-related thrombosis after left atrial appendage closure – A sub-analysis from the multicenter EUROC-DRT-registry. Echocardiography, 41(8), Article e15888. https://doi.org/10.1111/echo.15888

Klok, F. A., Vágó, E., Horváth-Puhó, E., Barco, S., Andersen, A., Bonnesen, K., Vonk-Noordegraaf, A., Delcroix, M., Konstantinides, S. V., Luijten, D., Cannegieter, S. C. & Sørensen, H. T. (2024). Incidence and clinical course of chronic thromboembolic pulmonary hypertension with or without a history of venous thromboembolism in Denmark. Journal of Thrombosis and Haemostasis, 22(12), 3562-3571. https://doi.org/10.1016/j.jtha.2024.09.006

Wood, G., Madsen, T. L., Kim, W. Y. & Lyhne, M. D. (2024). Increasing levels of positive end-expiratory pressure cause stepwise biventricular stroke work reduction in a porcine model. Anesthesiology, 140(2), 240-250. https://doi.org/10.1097/ALN.0000000000004821

Hørsdal, O. K., Gopalasingam, N., Lyhne, M. D., Ellegaard, M. S., Wethelund, K., Ravn, H. B., Wiggers, H., Christensen, S. & Berg-Hansen, K. (2024). Increasing Levels of Positive End-Expiratory Pressure Reduces Myocardial Oxygen Consumption in a Porcine Model of Cardiogenic Shock. Journal of the American College of Cardiology, 83(13, suppl). https://doi.org/10.1016/S0735-1097(24)04360-2

Nielsen-Kudsk, J. E., Andersen, A., Kramer, A., Eskildsen, V., Tiroke, L., Jensen, J. M., Linde Nørgaard, B. & Korsholm, K. (2024). Left Atrial Appendage Closure: What Is Fabric Edge Leak and How Can It Be Treated? JACC. Cardiovascular interventions, 17(19), 2312-2314. https://doi.org/10.1016/j.jcin.2024.08.007

Kramer, A. D. (2024). Left Atrial Appendage Closure Diagnosis and Prevention of Device-Related Thrombosis. [PhD dissertation, Aarhus University].

Kramer, A., Patti, G., Nielsen-Kudsk, J. E., Berti, S. & Korsholm, K. (2024). Left Atrial Appendage Occlusion and Post-procedural Antithrombotic Management. Journal of Clinical Medicine, 13(3), Article 803. https://doi.org/10.3390/jcm13030803

Aarnink, E. W., Maarse, M., Fierro, N., Mazzone, P., Beneduce, A., Tondo, C., Gasperetti, A., Pracon, R., Demkow, M., Zieliński, K., de Backer, O., Korsholm, K., Nielsen-Kudsk, J. E., Estévez-Loureiro, R., Caneiro-Queija, B., Benito-González, T., Pérez de Prado, A., Nombela-Franco, L., Salinas, P. ... STR-OAC LAAO and EWOLUTION Investigators (2024). Left Atrial Appendage Occlusion in Patients With Anticoagulation Failure vs Anticoagulation Contraindication. JACC. Cardiovascular interventions, 17(11), 1311-1321. https://doi.org/10.1016/j.jcin.2024.04.012

RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen Registry, and Verona Registry (2024). Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation. JAMA Neurology, 81(11). https://doi.org/10.1001/jamaneurol.2024.2882

Tiroke, L. H., Kramer, A., Poulsen, M. W., Jensen, C. D., Jensen, J. M., Nørgaard, B. L., Korsholm, K. & Nielsen-Kudsk, J. E. (2024). Long-term cardiac computed tomography follow-up after left atrial appendage occlusion. EuroIntervention, 20(11), e718-e727. https://doi.org/10.4244/EIJ-D-23-00802

Kianzad, A., Baccelli, A., Braams, N. J., Andersen, S., van Wezenbeek, J., Wessels, J. N., Celant, L. R., Vos, A. E., Davies, R., Giudice, F. L., Haji, G., Rinaldo, R. F., Vigo, B., Gopalan, D., Symersky, P., Winkelman, J. A., Boonstra, A., Nossent, E. J., Tim Marcus, J. ... Jan Bogaard, H. (2024). Long-term effects of pulmonary endarterectomy on pulmonary hemodynamics, cardiac function and exercise capacity in chronic thromboembolic pulmonary hypertension. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 43(4), 580-593. https://doi.org/10.1016/j.healun.2023.11.011

Giri, J., Mahfoud, F., Gebauer, B., Andersen, A., Friedman, O., Gandhi, R. T., Jaber, W. A., Pereira, K. & West, F. M. (2024). PEERLESS II: A Randomized Controlled Trial of Large-Bore Thrombectomy Versus Anticoagulation in Intermediate-Risk Pulmonary Embolism. Journal of the Society for Cardiovascular Angiography and Interventions, 3(6), Article 101982. https://doi.org/10.1016/j.jscai.2024.101982

Sun, X.-Q., Klouda, T., Barnasconi, S., Schalij, I., Schwab, J., Nielsen-Kudsk, A. H., Axelsen, J. S., Andersen, A., Aman, J., de Man, F. S., Bogaard, H. J., Yuan, K. & Yoshida, K. (2024). Pneumonectomy combined with SU5416 or monocrotaline pyrrole does not cause severe pulmonary hypertension in mice. American Journal of Physiology: Lung Cellular and Molecular Physiology, 327(2), L250-L257. https://doi.org/10.1152/ajplung.00105.2024

Korsholm, K., Iriart, X., Saw, J., Wang, D. D., Berti, S., Galea, R., Freixa, X., Arzamendi, D., De Backer, O., Kramer, A., Cademartiri, F., Cochet, H., Odenstedt, J., Aminian, A., Räber, L., Cruz-Gonzalez, I., Garot, P., Jensen, J. M., Alkhouli, M. & Nielsen-Kudsk, J. E. (2024). Position Statement on Cardiac Computed Tomography Following Left Atrial Appendage Occlusion. JACC: Cardiovascular Interventions, 17(15), 1747-1764. https://doi.org/10.1016/j.jcin.2024.04.050

Potpara, T., Grygier, M., Haeusler, K. G., Nielsen-Kudsk, J. E., Berti, S., Genovesi, S., Marijon, E., Boveda, S., Tzikas, A., Boriani, G., Boersma, L. V. A., Tondo, C., De Potter, T., Lip, G. Y. H., Schnabel, R. B., Bauersachs, R., Senzolo, M., Basile, C., Bianchi, S. ... Camm, A. J. (2024). Practical Guide on Left Atrial Appendage Closure for the Non-implanting Physician: An International Consensus Paper. EP Europace, 26(4), Article euae035. https://doi.org/10.1093/europace/euae035

Nørholt, C., Johannsen, C. M., Baltsen, C. D., Lund, M. H., Nielsen, L. K., Solberg, S. M. A., Hørsdal, O. K., Vammen, L., Lyhne, M. D., Andersen, L. W. & Granfeldt, A. (2024). Pulmonary vasodilation during cardiopulmonary resuscitation – a randomized, controlled porcine study. Resuscitation, 202, Article 110329. https://doi.org/10.1016/j.resuscitation.2024.110329

Hansen, J. V., Poulsen, M. W., Nielsen-Kudsk, J. E., Kalra, M. K., Lyhne, M. D. & Andersen, A. (2024). Quantitative pulmonary perfusion in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension. Pulmonary Circulation, 14(4), Article e12445. https://doi.org/10.1002/pul2.12445

Nielsen-Kudsk, J. E., Korsholm, K., Andersen, A., Jensen, J. M. & Nørgaard, B. L. (2024). Real changes in left atrial appendage occlusion practice in Denmark over time or inappropriate use of registry data? International Journal of Cardiology, 412, Article 132350. https://doi.org/10.1016/j.ijcard.2024.132350

Axelsen, J. S., Andersen, S., Ringgaard, S., Smal, R., Lluciá-Valldeperas, A., Nielsen-Kudsk, J. E., de Man, F. S. & Andersen, A. (2024). Right ventricular diastolic adaptation to pressure overload in different rat strains. Physiological Reports, 12(13), Article e16132. https://doi.org/10.14814/phy2.16132

Lyhne, M. D., Bikdeli, B., Jiménez, D., Kabrhel, C., Dudzinski, D. M., Moisés, J., Lobo, J. L., Armestar, F., Guirado, L., Ballaz, A., Monreal, M. & RIETE Investigators (2024). Right ventricular-pulmonary artery coupling for prognostication in acute pulmonary embolism. European Heart Journal: Acute Cardiovascular Care, 13(12), 817-825. https://doi.org/10.1093/ehjacc/zuae120

Bonnesen, K., Korsholm, K., Andersen, A., Pedersen, L., Ziegler Simonsen, C., Nielsen-Kudsk, J. E. & Schmidt, M. (2024). Risk of Ischemic Stroke After Patent Foramen Ovale Closure. Journal of the American College of Cardiology, 84(15), 1424-1433. https://doi.org/10.1016/j.jacc.2024.07.015

Kramer, A., Korsholm, K. & Nielsen-Kudsk, J. E. (2024). Single antiplatelet therapy following Amplatzer left atrial appendage occlusion. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 20(5), e301-e311. https://doi.org/10.4244/EIJ-D-23-00684

Pastormerlo, L. E., De Caterina, A. R., Esposito, A., Korsholm, K. & Berti, S. (2024). State-of-the-Art of Transcatheter Left Atrial Appendage Occlusion. Journal of Clinical Medicine, 13(4), Article 939. https://doi.org/10.3390/jcm13040939

Lyhne, M. D., Liteplo, A. S., Zeleznik, O. A., Dudzinski, D. M., Andersen, A., Shokoohi, H., Al Jalbout, N., Eke, O. F., Morone, C. C., Huang, C. K., Heyne, T. F., Kalra, M. K. & Kabrhel, C. (2024). Supplemental oxygen for pulmonary embolism (SO-PE): study protocol for a mechanistic, randomised, blinded, cross-over study. BMJ Open, 14(11), e091567. Article e091567. https://doi.org/10.1136/bmjopen-2024-091567

Briceño, W., Díaz, G., Castillo, A., Jara, I., Yong, E., Lago, L., Dam Lyhne, M., Monreal, M., Bikdeli, B. & Jimenez, D. (2024). Time to Resolution of Right Ventricle Dysfunction in Patients With Acute Pulmonary Embolism. Archivos de Bronconeumologia, 60(7), 448-450. https://doi.org/10.1016/j.arbres.2024.03.001

Bshennaty, A., Vogl, B. J., Bavo, A. M., Sularz, A., Kramer, A. D., Jia, Y., De Beule, M., Nielsen-Kudsk, J. E., De Backer, O., Alkhouli, M. & Hatoum, H. (2024). Understanding the role of the left atrial appendage on the flow in the atrium. Catheterization and Cardiovascular Interventions, 104(6), 1290-1298. https://doi.org/10.1002/ccd.31153

RIETE Investigators (2024). Validation of Echocardiographic Measurements in Patients with Pulmonary Embolism in the RIETE Registry. TH open, 8(1), e1-e8. https://doi.org/10.1055/s-0043-1777765

Lakkireddy, D., Thaler, D., Ellis, C. R., Swarup, V., Gambhir, A., Hermiller, J., Nielsen-Kudsk, J. E., Worthley, S., Nair, D., Schmidt, B., Horton, R., Gupta, N., Anderson, J. A., Gage, R., Alkhouli, M. & Windecker, S. (2023). 3-Year Outcomes From the Amplatzer Amulet Left Atrial Appendage Occluder Randomized Controlled Trial (Amulet IDE). JACC. Cardiovascular interventions, 16(15), 1902-1913. https://doi.org/10.1016/j.jcin.2023.06.022

Maagaard, M., Boutrup, N., Udholm, S., Ahlstrup, M., Nielsen-Kudsk, J. E., Ringgaard, S. & Hjortdal, V. (2023). Adults with small, unrepaired atrial septal defects have reduced cardiac index during exercise. Cardiology in the Young, 33(10), 1981-1991. https://doi.org/10.1017/S1047951122003742

Nielsen-Kudsk, J. E., Andersen, A., Korsholm, K. & Grove, E. L. (2023). Antithrombotic therapy in patients with patent foramen ovale (PFO), PFO closure, left ventricular mural thrombus, atrial thrombus, and catheter-related thrombosis. In Antithrombotic therapy in patients with patent foramen ovale (PFO), PFO closure, left ventricular mural thrombus, atiral thrombus, and catheter-related thrombosis (pp. 221-230). Oxford University Press.

Dragsbaek, S. J., Lyhne, M. D., Hansen, J. V., Pedersen, C. C. E., Jujo-Sanada, T., Karout, L., Kalra, M. K., Nielsen-Kudsk, J. E. & Andersen, A. (2023). A porcine model of human-like chronic thromboembolic pulmonary disease. Thrombosis Research Supplement, 231, 25-28. https://doi.org/10.1016/j.thromres.2023.09.011

Lyhne, M. D., Giordano, N., Dudzinski, D., Torrey, J., Wang, G., Zheng, H., Parry, B. A., Kalra, M. K. & Kabrhel, C. (2023). Authors' reply. Emergency Radiology, 30(4), 565-566. https://doi.org/10.1007/s10140-023-02145-6

Lang, I. M., Andreassen, A. K., Andersen, A., Bouvaist, H., Coghlan, G., Escribano-Subias, P., Jansa, P., Kopec, G., Kurzyna, M., Matsubara, H., Meyer, B. C., Palazzini, M., Post, M. C., Pruszczyk, P., Räber, L., Roik, M., Rosenkranz, S., Wiedenroth, C. B., Redlin-Werle, C. & Brenot, P. (2023). Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: a clinical consensus statement of the ESC working group on pulmonary circulation and right ventricular function. European Heart Journal, 44(29), 2659-2671. https://doi.org/10.1093/eurheartj/ehad413

Andersen, S., Reese-Petersen, A. L., Braams, N., Andersen, M. J., Mellemkjær, S., Andersen, A., Bogaard, H. J., Genovese, F. & Nielsen-Kudsk, J. E. (2023). Biomarkers of collagen turnover and wound healing in chronic thromboembolic pulmonary hypertension patients before and after pulmonary endarterectomy. International Journal of Cardiology, 384, 82-88. https://doi.org/10.1016/j.ijcard.2023.05.016

Kramer, A. D., Korsholm, K., Jensen, J. M., Nørgaard, B. L., Peelukhana, S., Herbst, T., Horton, R., Kar, S., Saw, J., Alkhouli, M. & Nielsen-Kudsk, J. E. (2023). Cardiac computed tomography following Watchman FLX implantation: device-related thrombus or device healing? European Heart Journal Cardiovascular Imaging, 24(2), 250-259. https://doi.org/10.1093/ehjci/jeac222

Thangavel, S., Korsholm, K., Veien, K. T., Larsen, K. M. & Andersen, A. (2023). Catheter-directed mechanical thrombectomy in a patient with high-risk pulmonary embolism complicated by out-of-hospital cardiac arrest: A case report. European Heart Journal - Case Reports, 7(7), Article ytad307. https://doi.org/10.1093/ehjcr/ytad307