Research Year Students: Johanne Ravn Hansen and Sara Hillerup

Evaluating the vulnerability of conventional and transposition FAMM flaps using microdialysis

Surgery is a key component in the treatment of oral cavity cancer, but it often leads to complex
defects, requiring reconstruction to re-establish form and function. For this purpose, two tissue
flaps can be used: A conventional Facial Artery Musculomucosal (FAMM) flap and the transposition
FAMM flap, the latter being associated with less morbidity compared to the conventional FAMM
flap, but more fragility due to flap necrosis. No studies have investigated the underlying reasons.
Microdialysis is a promising method allowing for continuous sampling from multiple target tissues.
This study aims to monitor and compare inflammatory protein markers and ischemic metabolites
within the flaps and to evaluate different administration forms of cefuroxime and metronidazol
(bolus vs continuous infusion; intravenous vs per oral). This project may ultimately provide
significant benefits for the functional recovery of patients with oral cavity cancer and reduce
expenses of our health care system.